In this study, we investigate the viscoelasticity-induced migration of solid particles immerged in three-dimensional flow field created by rotation a Rushton turbine. At same time, propose scaling law for predicting characteristic particle time as function Weissenberg number. Particle image velocimetry is adopted to reconstruct velocity and deformation rate fields generated turbine both Newtoni...

Rationale and significance. Recombinant therapeutic proteins are frequently produced in mammalian cells cultivated in suspension in large-scale stirred tank bioreactors. There are three major drawbacks to stirred-tank bioreactors. First, they are expensive to purchase and maintain, limiting their availability to some potential users. Second, they have not been adapted to volumetric scales less ...

Stirred tanks are widely used in process industries for blending of singleand/or multiple-phase fluids, which often involves mass and/or heat transfer, chemical reactions, etc. Deep knowledge of flow field in the stirred tank is necessary to carry out these unit operations efficiently. As a result, extensive investigations of the flow in stirred tanks have been conducted over the past several d...

We consider the mixing dynamics of an air–liquid system driven by rotation a pitched blade turbine (PBT) inside open, cylindrical tank. To examine flow and interfacial dynamics, we use highly parallelised implementation hybrid front-tracking/level-set method that employs domain-decomposition parallelisation strategy. Our numerical technique is designed to capture faithfully complex deformation,...

In a gas-liquid stirred reactor, gas tends to accumulate in low-pressure regions behind the impeller blades. Such gas accumulation forming so-called gas cavities, significantly alters impeller performance characteristics. We have computationally investigated gas-liquid flow generated by a Rushton turbine. Rotating Rushton turbine generates trailing vortices behind the blades, which enhance the ...

The ability to culture hematopoietic cells in readily characterizable and scalable stirred systems, combined with the capability to utilize serum-free medium, will aid the development of clinically attractive bioreactor systems for transplantation therapies. We thus examined the proliferation and differentiation characteristics of peripheral blood (PB) mononuclear cells (MNC), cord blood (CB) M...