Head direction (HD) cells in the rodent limbic system are believed to correspond to a cognitive representation of directional heading in the environment. Lesions of vestibular hair cells disrupt the characteristic firing patterns of HD cells, and thus vestibular afference is a critical contributor to the HD signal. A subcortical pathway that may convey this information includes the dorsal tegme...

The neural representation of directional heading is conveyed by head direction (HD) cells located in an ascending circuit that includes projections from the lateral mammillary nuclei (LMN) to the anterodorsal thalamus (ADN) to the postsubiculum (PoS). The PoS provides return projections to LMN and ADN and is responsible for the landmark control of HD cells in ADN. However, the functional role o...

Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve up to the level of the anterior horn cell. A variety of hereditary causes are recognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of familial motor neuron disease. Recent genetic advances have resulted ...

Historic changes in the criteria for pathologic diagnosis and classification of lupus membranous nephropathy (LMN) have precluded definitive descriptions of the natural history, prognosis, and treatment of this disorder. The interim practice, based on the 1982 World Health Organization classification system, of admixing membranous and proliferative lupus nephropathies under the rubric of LMN ha...

The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projections to the lateral mammillary nucleus (LMN), involved in generating the head direction signal. Th...

OBJECTIVE Progressive muscular atrophy (PMA) is a clinical diagnosis characterised by progressive lower motor neuron (LMN) symptoms/signs with sporadic adult onset. It is unclear whether PMA is simply a clinical phenotype of amyotrophic lateral sclerosis (ALS) in which upper motor neuron (UMN) signs are undetectable. To elucidate the clinicopathological features of patients with clinically diag...

Many neurons in the rat anterodorsal thalamus (ADN) and postsubiculum (PoS) fire selectively when the rat points its head in a specific direction in the horizontal plane, independent of the animal's location and ongoing behavior. The lateral mammillary nuclei (LMN) are interconnected with both the ADN and PoS and, therefore, are in a pivotal position to influence ADN/PoS neurophysiology. To fur...

Lasting complete denervation is the result of lower motor neuron (LMN) or peripheral nerve lesions that have major consequences on the muscle tissue. The human time course from atrophy to degeneration in large mammals lasts longer (in years) than generally accepted. After early atrophy, the midand late-phases presents two very contrasting myofibers populations: beside those severely atrophic wi...

Developing techniques for mobile robot navigation constitutes one of the major trends in the current research on mobile robotics. This paper develops a local model network (LMN) for mobile robot navigation. The LMN represents the mobile robot by a set of locally valid submodels that are Multi-Layer Perceptrons (MLPs). Training these submodels employs Back Propagation (BP) algorithm. The paper p...