The diseases of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterized by mucus-congested airways. Agents that stimulate the secretion of Cl- are anticipated to facilitate mucociliary clearance and thus be of benefit in the treatment of CF and COPD. Recently 1-EBIO (1-ethyl-2-benzimidazolinone or 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) was shown to stimulate ...

CLINICAL SCENARIO Patellofemoral pain syndrome (PFPS) is one of the most common disorders affecting the lower extremities. To improve function and decrease pain, affected individuals often undergo a guided rehabilitation program. Traditional programs have concentrated on quadriceps strengthening and other knee-focused exercises, but recent literature suggests that adding hip-muscle strengthenin...

In the aftermath of the Ebola crisis and with renewed attention to resilient health systems, the process of improving approaches of global health actors to health systems strengthening is of great relevance. Despite the increased amount of attention paid to health systems strengthening, there is no standard definition of this concept among global health actors. Germany is no exception. Though t...

Previous studies investigating domain-initial prosodic strengthening have shown that consonants undergo cumulative strengthening at the beginning of prosodic domains. However, evidence for articulatory strengthening of domain-initial vowels is sparse [1], [2]. At least two possible hypotheses exist why vowels fail to show domain-initial strengthening: a) Domain-initial strengthening only target...

The use of composite materials for strengthening the ailing infrastructure has steadily gained acceptance and market share. Employing composite materials in strengthening of steel structures is the subject of this study. There are several challenges that face strengthening steel structures using composite materials. The superior mechanical properties of steel result in a reduction in the effici...