Wang, Rui, Yuejin Wu, Guanghua Tang, Lingyun Wu, and Salma Toma Hanna. Altered L-type Ca21 channel currents in vascular smooth muscle cells from experimental diabetic rats. Am. J. Physiol. Heart Circ. Physiol. 278: H714– H722, 2000.—Vascular complications of diabetes are associated with abnormal Ca21 handling by vascular smooth muscle cells (SMCs) in which the alteration in L-type voltagedepend...

Herbal therapies are commonly used to treat or manage various diseases including diabetes mellitus. Pimpinella tirupatiensis is Indian traditional medicine and the plant has been a popular remedy for various diseases such as antitumor genic, antimicrobial, purgative, analgesic, antiseptic, antipyretic and anti-inflammatory. The current study was intended to evaluate the antidiabetic efficacy of...

Background: Globally, medicinal plants are widely used to treat ailments due their safety, accessibility and efficacy. Objectives: The objective of this study was determine in vivo neuroprotective effect methanolic extract seeds Cydonia oblongaagainst streptozotocininduced diabetes rats, as research has not been reported previously. Methods: Methanolic (100, 150 200 mg/kg b.w) administered for ...

Asafoetida, an oleo-gum-resin obtained from the roots of Ferula assafoetida, is used in traditional medicine to treat various diseases including, asthma, epilepsy, gastrointestinal disorders and influenza. The aim of the current study was to evaluate the hypoglycemic activity of the asafoetida extract in streptozotocininduced diabetic rats. Male Wistar rats were randomly divided into 5 groups, ...

BACKGROUND In Mexican traditional medicine, the seeds of Byrsonima crassifolia have been used in the treatment of diabetes, rheumatism and for wound healing. The aim was to evaluate the effect of seeds of B. crassifolia on insulin release from the pancreatic beta cells in streptozotocininduced diabetic rats. MATERIALS AND METHODS In the present study, we evaluated the beneficial effect of see...

Diabetes mellitus is a common chronic metabolic disease that is of increasing concern, because it frequently leads to complications such as cardiovascular diseases and cancer. Plants have been studied as a potential source for anti-diabetics to supplement dietary modifications, insulin, and other medications. The components of green tea polyphenols can be changed by processes such as browning. ...

Background: Oxidative stress forms the foundation for the induction of multiple cellular pathways which can lead to the complications of diabetes mellitus that the most debilitating ones are diseases of the nervous system. In this study, we evaluated whether treadmill running could alleviate oxidative stress and apoptosis rate in the hippocampus of streptozotocininduced diabetic rats. Methods: ...

Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG. High -cell mass prevents streptozotocininduced diabetes in thioredoxin-interacting protein-deficient mice. Am J Physiol Endocrinol Metab 296: E1251–E1261, 2009. First published February 17, 2009; doi:10.1152/ajpendo.90619.2008.— Thioredoxin-interacting protein (TxNIP) is an endogenous inhibitor of thioredoxin, a ubi...

OBJECTIVES Okra (Abelmoschus esculentus) is a tropical vegetable that is rich in carbohydrates, fibers, proteins and natural antioxidants. The aim of the present study was to evaluate the effects of Okra powder on pancreatic islets and its action on the expression of PPAR-γ and PPAR-α genes in pancreas of high-fat diet (HFD) and streptozotocininduced diabetic rats. MATERIALS AND METHODS In th...