Nat. Chem. Biol. 12 i–iii (2016); published online 19 January 2016; corrected after print 11 February 2016 In the version of this caption initially published, the cover artwork was credited to Erin Dewalt, based on imagery from the author, rather than stating that it was created by Michael B. Battles and the design was by Erin Dewalt. The error has been corrected in the HTML and PDF versions of...

The final stage of cell division (mitosis), involves the compaction of the duplicated genome into chromatid pairs. Each pair is captured by microtubules emanating from opposite spindle poles, aligned at the metaphase plate, and then faithfully segregated to form two identical daughter cells. Chromatids that are not correctly attached to the spindle are detected by the constitutively active spin...

mounted, though, I began to recognize that, just as chronic stress modified the brains and behavior of my mice, my peers were experiencing something similar. We tended to refer to these changes—which included feeling downtrodden and anxious, withdrawing from social activities, and losing much of our enthusiasm for science—as the “thirdyear blues,” which made them seem expected and even normal. ...