BACKGROUND AND AIMS Based on conflicting reports regarding the role of the fibrotic stromal response in cancer development--namely, that a desmoplastic reaction can favour either the host or the tumour--it is clear that the role of the stromal response is varied. We have classified the fibrotic stroma of rectal adenocarcinoma penetrating the muscularis propria, based on histologically identifie...

Background and aims: Based on conflicting reports regarding the role of the fibrotic stromal response in cancer development—namely, that a desmoplastic reaction can favour either the host or the tumour—it is clear that the role of the stromal response is varied. We have classified the fibrotic stroma of rectal adenocarcinoma penetrating the muscularis propria, based on histologically identified...

Purpose: To investigate choroidal alterations in patients with thyroid eye disease (TED) using swept-source optical coherence tomography (SS-OCT) and compare them age-matched healthy controls. Methods: SS-OCT scans were performed to obtain quantitative measurements of parameters. Mean thickness (MCT), vessel volume (CVV), stroma (CSV), vascularity index (CVI), stroma-to-vessel ratio (CSVR) calc...

PURPOSE Marked reactive stroma formation, designated as grade 3 reactive stroma, is associated with poor outcome in clinically localized prostate cancer. To understand the biological processes and signaling mechanisms underlying the formation of such reactive stroma, we carried out microarray gene expression analysis of laser-captured reactive stroma and matched normal stroma. EXPERIMENTAL DE...

The syndrome of disseminated intravascular coagulation (DIC) 1 is a recognized complication of acute hemolytic episodes in both man (1-3) and laboratory animals (4, 5) and has been induced experimentally in monkeys and dogs by infusion of autologous red blood cell stroma (6, 7). The mechanism of stromainduced D I C may be analogous to the demonstrable procoagulant activity of red cell membrane ...

Pancreatic ductal adenocarcinomas with high stromal content are shown to have greatly reduced overall survival, consistent with previous reports that stroma may limit drug delivery. In contrast to expectations, metastatic lesions were found to harbor as much stroma as primary tumors.

The central odontogenic fibroma (COF) is a rare benign mesenchymal tumour of jaw bone derived from the ectomesenchyme. It characterized by fibrous mature stroma with variable number strands or islands inactive-looking epithelium. presented case 46 years old male complaining asymptomatic mandibular bony swelling. Radiographically, lesion unilocular radiolucent, root resorption and displacement t...