Cycloaddition reactions of tetrakis(hexyloxy)-substituted 2,3-triphenylyne (2,3-didehydrotriphenylene) provide straightforward access to three new cata-condensed polyarenes characterized by the presence of 5, 8 and 11 fused benzene rings.

This paper investigates the local linear model tree (LOLIMOT), a typical neural fuzzy model, in multiple-input-multiple-output predictive control (MPC). In conventional LOLIMOT, structural parameters including centres and variances of its Gaussian kernels are set based on equally dividing input data space. this paper, after initially obtained from space partition, they optimized by gradient des...

NIH3T3 cells stably expressing the rat 5-hydroxytryptamine 2A (5-HT 2A) receptor (5500 fmol/mg) were used to explore further the capacity of structurally distinct ligands to elicit differential signaling through the phospholipase C (PLC) or phospholipase A 2 (PLA 2) signal transduction pathways. Initial experiments were designed to verify that 5-HT 2A receptor-mediated PLA 2 activation in NIH3T...

Dynamical systems methods are used to investigate a cosmological model with non-minimally coupled scalar field and asymptotically quadratic potential function. We found that for values of the non-minimal coupling constant parameter 3 16 < ξ 1 4 there exists an unstable asymptotic de Sitter state, free from parallelly propagated singularity 5 24 ≤ , giving rise non-singular beginning universe. T...

One of the main theoretical issues in developing a theory anisotropic viscoelastic media at finite strains lies proper definition material symmetry group and its evolution with time. In this paper matter is discussed thoroughly addressed by introducing novel remodelling equation compatible principle structural frame indifference, requirement that every inelastic based on multiplicative decompos...

Specific signals (degrons) regulate protein turnover mediated by the ubiquitin-proteasome system. Here we systematically analyse known degrons and propose a tripartite model comprising the following: (1) a primary degron (peptide motif) that specifies substrate recognition by cognate E3 ubiquitin ligases, (2) secondary site(s) comprising a single or multiple neighbouring ubiquitinated lysine(s)...

PURPOSE The clinically approved oncogenic BRAF inhibitor PLX4032 (vemurafenib) was shown to be a substrate of the ATP-binding cassette (ABC) transporter ABCB1. Here, we compared PLX4032 and its structurally closely related precursor compound PLX4720 for their interference with ABCB1 and the ABCB1-mediated compound transport using docking and cell culture experiments. METHODS For the docking s...