Dendroaspis natriuretic peptide (DNP) shares a functionally important sequence homology with other natriuretic peptides. However, the characteristics of DNP and its receptor in the context of diabetes remafin to be fully elucidated. In the present study, alterations in the plasma levels and tissue contents of DNP and the properties of its receptor in diabetic rats, induced by streptozotocin (ST...

The present study was carried out to evaluate the antihyperglycemic property of Terminalia arjuna in streptozotocin-induced type 2 diabetic model rats. To and antioxidant role ethanol extract leaf Hyperglycemia induced rats by single intraperitoneal injection streptozotocin (STZ, 120mg/kg body weight). Three days after STZ induction, hyperglycemic were treated with a dilution bark T. orally at ...

objective(s):diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (tgf-β). fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent tgfβ1 modulator. in this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromod...

Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids disorder to normal level is clinically very important. The aim of present study was to evaluate the effects of Berberis integerrima Bge. fruit aqueous extract (BIFAE) on blood glucose and lipid profile in streptozotocin (STZ) - induced diabetic rats. The STZ-induced diabetic rat were treated by fruit aqueous extr...

BACKGROUND It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. METHODS About a half of two-day...

In the area of drug discovery, repurposing strategies represent an approach to discover new uses approved drugs besides their original indications. We used this investigate effects dimethyl fumarate (DMF), a for relapsing–remitting multiple sclerosis and psoriasis treatment, on early injury associated with diabetic retinopathy (DR). in vivo streptozotocin (STZ)-induced rat model. Diabetes was i...

The aqueous extract of Syzygium cumini (Pulp) was investigated for its possible hypoglycemic and antioxidant potentials in streptozotocin (STZ) induced diabetic wistar female rats. A single intraperitoneal injection of STZ at a dose of 55 mg/kg body weight elevated the glucose levels more than 230 mg/dl after 3 days. Treatment with the aqueous extract of Syzygium cumini (Pulp) at 100 mg/kg ...

objective: the aim of the present study was to investigate the renal protective effect of adenanthera pavonina (a. pavonina) seed aqueous extract (apsae), in streptozotocin (stz)-induced diabetic rats. materials and methods: the renal protective effect of a. pavonina seed aqueous extract (apsae) was studied in stz-induced diabetic rats. apsae (50, 100 and 200 mg/kg per day) was given daily to d...

We investigated the effect of an albumin infusion on enzyme activity, expression level cytochrome P450 2E1 (CYP2E1), and oxidative stress in serum liver streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced alanine aminotransferase aspartate activities rat compared with those untreated Treatment elevated catalytic activity CYP2E1, stress, decreased reducing potentials liver, su...

− The aim of this study was to evaluate the anti-diabetic effects of the water extract of Lespedeza cuneata (LCW) using rat insulinoma (RIN) m5F cells and streptozotocin (STZ)-induced diabetic rats. The effect of LCW on the protection of pancreatic beta cells was assessed using MTT assay, and nitric oxide production was assessed using Griess reagent. STZ-induced diabetic rats were treated with ...