The bioavailability of propranolol depends on the degree of liver metabolism. Orally but not intravenously administered propranolol is heavily metabolized. In the present study we assessed the pharmacokinetics and pharmacodynamics of sublingual propranolol. Fourteen severely hypertensive patients (diastolic blood pressure (DBP) > or = 115 mmHg), aged 40 to 66 years, were randomly chosen to rece...

OBJECTIVE To identify an effective misoprostol-only regimen for termination of pregnancy between 12 and 20 weeks of gestation, a prospective randomized study comparing sublingual, vaginal, and oral routes of administration of misoprostol was done. METHODS One hundred and fifty women (12-20 weeks gestation) were randomly divided into three groups and given 400 mcg misoprostol sublingually, vag...

OBJECTIVE To evaluate the effect of sublingual administration of ISDN on the results of the head-up tilt table test (HUTT) in children and adolescents with vasovagal syncope. MATERIALS AND METHODS The study group consisted of 30 children, each with at least one incidence of vasovagal syncope, and the control group had 15 healthy children. The patients were tilted upright at an angle of 60° fo...

BACKGROUND Misoprostol is widely used in obstetrics and gynaecology for medical abortion, cervical priming and induction of labour. To aid the design of effective and safe regimens, we have investigated the pharmacokinetic parameters after the vaginal or sublingual administration of repeated doses of 400 microg of misoprostol. METHODS Women undergoing termination of pregnancy by suction evacu...

Submit Manuscript | http://medcraveonline.com J Anesth Crit Care Open Access 2015, 3(2): 00085 of first pass metabolism so it provides better bioavailability. It is a non invasive and painless route of administration. It is also suitable for patients with nausea, vomiting, dysphagia, gastrointestinal disturbance such as obstruction. The systemic drug delivery after sublingual route is fast as d...

BACKGROUND AND OBJECTIVES Hypertensive crisis is a condition characterized by rapid and inappropriate symptomatic elevation of blood pressure (BP) that is commonly seen in Emergency Departments. Oral or sublingual captopril is commonly used in the Emergency Departments. The unpleasant taste of the sublingual drugs causes uncomfortable condition to the patient. Studies showing no difference betw...

BACKGROUND The sublingual administration of opioids is a simple and noninvasive method that provides rapid analgesia. In this phase I study we investigated the pharmacokinetics and bioavailability of a fentanyl wafer in healthy volunteers. The principal study objective was to investigate the pharmacokinetic profile of a new sublingual fentanyl wafer and to establish its absolute bioavailability...

Background: To identify an effective misoprostol-only regime for the termination of second trimester pregnancy. Objectives: To compare the efficacy, safety and acceptability of sublingual and vaginal misoprostol for second trimester pregnancy termination. Methods: In a prospective randomized comparative study, over 138 pregnant women at 13 20 weeks (91 140 days) of gestation requiring medical a...