Ribonucleotide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.

Suicide has become a significantly prominent issue because high frequencies of occurrences make it one of the top three causes of death for young people in the United States. To prevent suicide attempts, it is important to identify suicidal tendencies in the behavior, speech, or writing of an individual as early as possible. This paper demonstrates one technique of analyzing written material to...

OBJECTIVE Our aims were (1) to develop 2 inventories for the measurement of cognitive and emotional attitudes toward borderline personality disorder (BPD) patients and their treatment and (2) to use these tools to understand and compare attitudes of psychiatrists, psychologists, and nurses toward BPD patients. METHOD Two lists of items referring to cognitive (47 items) and emotional attitudes...

This study draws on the social stress model from the sociology of mental health to examine the impact of same-sex attraction on depressed mood and suicidal tendencies. Specifically, we hypothesize that across multiple contexts, adolescents with same-sex attractions are likely to experience more social stress and less social support than heterosexual adolescents. In turn, these experiences incre...

Hardik A. Patel, Cheng-Yuan Hsieh Knowledge Systems Institute Abstract—This paper presents an application, wherein predictive analysis is used to churn social media comments and posts for identifying individuals on these sites susceptible to suicidal thoughts and tendencies. So an early intervention could be made saving lives of such individuals. Also presented is a model wherein a branch of bi...

Based on clinical experience, anecdotal reports, and past empirical and conceptual work, we predicted that when people with narcissistic tendencies experience depressive symptoms, they are prone to develop paranoid attitudes. Moreover, we expected that this process was unidirectional, and that the combination of paranoid tendencies and depressive symptoms would not be associated with an increas...

Clinical psychological discourse contains a varied array of evaluations of the risks and/or benefits of Internet message boards where people can discuss their suicidal thoughts. Public opinion contends they are harmful. To assess this assumption, an online questionnaire (N = 164) survey was conducted on a German message board for suicidal people. Three user types were identified with differing ...

The Multi-Attitude Suicide Tendency Scale (MAST) was designed to assess suicidal tendencies in youth. This 30-item scale has four types of attitudes: attraction to life, repulsion by life, attraction to death, and repulsion by death. Normative, factor structure, and psychometric data were investigated with American youth with a range of suicidal ideations and behaviors. The reported factor stru...

Suicidal tendencies and ideationsare not limiting up to the developing nations today making it more vulnerable for research as people of science around world want know about neurobiology behind suicidal ideation. Which neurochemical pathway decide method suicide chosen, fatality chosen multiplicity methods. Authors here reviewed various databases on related topic tried conclude theories based c...