It is well known that the incorporation of wetting agents in drug solutions for local application enhances the penetration of the drug into the tissues (McKee et al., 1943; Bellows and Gutman, 1943; Trim and Alexander, 1946). Ginsburg and Robson (1945) have shown that when dodecyl sodium sulphate is incorporated in solutions of sodium sulphacetamide applied to the cornea, the increase in penetr...

this work. We are also indebted to the " W. H. Ross Foundation (Scotland) for the Prevention of Blindness," who have defrayed the expenses of this investigation; to Sir Henry Dale, who kindly gave us some of his supply of tyrothricin; to Dr. Trevan, of the Weilcome Research Foundation, who kindly supplied us with penicillin made by Dr. Pope and Miss Stevens; and to Mr. Edwards, of British Scher...

Successful management of acne requires careful patient evaluation followed by consideration of several patient and medication factors when selecting a particular therapeutic regimen. Within the last few years, several new agents for the treatment of acne have become available that afford greater flexibility in the treatment of this prevalent dermatologic disorder. These include adapalene, tazar...

Sulfonamides were extracted from honey with acetate buffer (pH 5.0), and cleaned up by solid phase extraction (SPE) procedure. The liquid chromatography (LC) separation was carried out on RP C18 column using acetic acid and acetonitrile as the mobile phase in gradient mode and monitored with fluorescence detector, after pre-column derivatisation. Recoveries from spiked honey were above 80%, and...

1. The penetration of sodium sulphacetaamide into the ocular tissues has been studied, both in living'rabbits and in isolated ocular tissues. 2. Application of the drug with a wetting agent, Duponal ME dry, increases the penetration of sodium sulphacetamide into and through the cornea. 3., Removal of the corneal epithelium causes a great increase in the penetration of the sulphonamide into antd...

One hundred fifty-eight patients, 21 years of age or less, presenting with culture-positive (Haemophilus influenzae or Streptococcus pneumoniae) conjunctivitis were treated with trimethoprim-polymyxin B (TP), gentamicin sulfate (GS) or sodium sulfacetamide (SS) ophthalmic solution for 10 days. Clinical response at 3 to 6 days after start of therapy was similar for all test agents: 26 of 55 (47%...

A variety of novel 5-aryl thiophenes 4a-g containing sulphonylacetamide (sulfacetamide) groups were synthesized in appreciable yields via Pd[0] Suzuki cross coupling reactions. The structures of these newly synthesized compounds were determined using spectral data and elemental analysis. Density functional theory (DFT) studies were performed using the B3LYP/6-31G (d, p) basis set to gain insigh...

Antibiotics have been used to control the aquatic environment in both therapeutic and prophylactic ways. are particularly difficult extract due their strong interactions with biological matrices. In this study, UPLC-MS/MS method was developed validated for quantitative confirmatory analysis of multi-class antibiotics residues fish shrimp. Fourteen belonging sulphonamides, β-lactams, quinolones,...

Although currently recommended antibiotics for Lyme disease such as doxycycline or amoxicillin cure the majority of the patients, about 10-20% of patients treated for Lyme disease may experience lingering symptoms including fatigue, pain, or joint and muscle aches. Under experimental stress conditions such as starvation or antibiotic exposure, Borrelia burgdorferi can develop round body forms, ...