A series of interesting sulfonamides containing hydroxyl group were synthesized under solvent-free conditions. The synthetic route involves the selective reaction of amino alcohol and sulfonating agents. The sulfonamides were obtained by simple procedure after an easy work-up in high yield and purity, and characterized by IR, 1H NMR and 13C NMR analysis. These compounds were tested for antibact...

Earlier workers suggested that synergism of polymyxin and sulfonamides occurred because sulfonamides produced changes in the cell wall which permitted the more ready access of polymyxin. We tested this hypothesis by using L-forms, which lack cell wall. The demonstration that synergism of polymyxin and sulfonamides occurs in L-forms of Proteus mirabilis and Staphylococcus aureus suggested that t...

The photocatalytic degradation of sulfonamides in aqueous TiO2 suspension under UV irradiation has been investigated using potassium ferrate as electron acceptors. The results showed that the stability of Fe(VI) is dependent on pH significantly, and the stability reduces obviously in the presence of UV-TiO2. The experiments indicated that Fe(VI) could effectively scavenge the conduction band el...

1. In vitro experiments were performed with E. coli, using a method designed for the quantitative study of various aspects of sulfonamide resistance. 2. Resistance was found to be a gradually developing process, and was demonstrated for all four drugs tested, sulfanilamide, sulfapyridine, sulfathiazole, and sulfadiazine. 3. It was shown that the degree of resistance developed was correlated wit...

sulfonamides are the first effective chemotherapeutic agents used for several years to cure or prevent systemic bacterial infections. in addition, this agents showed anti-carbonic anhydrase and cause cell cycle perturbation in the g1 phase, disruption of microtubule assembly, suppression of the transcription activator nf-y, angiogenesis and matrix metalloproteinase (mmp). in recent years, novel...

In recent years it has been established that sulfonamides inhibit the respiration of certain bacteria, yeasts, and tissues. This inhibition was first observed on intact bacteria by Barron and Jacobs (l), and it seems to occur simultaneously with the cessation of growth in the presence of the sulfonamide (2). On the basis of numerous investigations, it can be assumed that certain relationships e...

The biological importance of p-aminobenzoic acid was recognized only in 1940 when Woods showed that the compound antagonized the bacteriostatic effects of sulfonamides (2). Later, p-aminobenzoic acid was found to be an essential part of the folic acid molecule (3, 4), and it now seems quite likely that the sole metabolic function of p-aminobenzoate is to serve as a precursor for the biosynthesi...

A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.

In recent years it has been established that sulfonamides inhibit the respiration of certain bacteria, yeasts, and tissues. This inhibition was first observed on intact bacteria by Barron and Jacobs (l), and it seems to occur simultaneously with the cessation of growth in the presence of the sulfonamide (2). On the basis of numerous investigations, it can be assumed that certain relationships e...

Sulfonamides are drugs extensively used for the treatment of certain infections caused by gram-positive and gram-negative microorganisms, some fungi, and certain protozoa. Several physical and chemical parameters of these compounds have been correlated with their chemotherapeutic activity: pK a , protein binding, and electronic charge distribution, among others. Unfortunately, no single paramet...