With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch gly...

The aim of the present study is to evaluate the gum Dikamali as a sustained release polymer employing zidovudine as a model drug. Natural gums are economic, easily available and found useful as Pharmaceutical excipients. To the best of our knowledge, no significant work has been reported on dikamali. Zidovudine was received as a gift sample from Hetero Drugs Private limited (Jeedimetla, Hyderab...

BACKGROUND Orally disintegrating tablets (ODTs) are a modern form of tablets that when placed in the oral cavity, disperses rapidly. These tablets have advantages, particularly good applications for children and old patients who have a complication in chewing or swallowing solid dosage forms. The aim of this study was to design, formulate, and evaluate the physicochemical properties of 5 mg mon...

Seed starch (16.0%w/w) obtained from Abelmoschus moschatus Linn. (Malvaceae) was employed as a disintegrant to paracetamol tablets at concentrations of 2.5-10.0% w/w. The granules prepared by wet granulation technique were evaluated for percentage of fines and flow properties. Tablet properties including thickness, content uniformity, average weight and weight variation, hardness, friability, d...

The aim of this study was to modify the sago starch and evaluate its efficacy as tablet disintegrant. Cross-linked carboxymethylated sago starch (CMSS) was synthesized using native sago starch (SS) and monochloroacetic acid (MCA) with sodium hydroxide in microwave radiation environment. FT-IR analysis of the sample confirmed the carboxymethylation by showing absorption peak at 1607.2 cm. CMSS w...

PURPOSE The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant. METHODS Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of th...

Many patients especially children and elderly have difficulty in swallowing tablets and capsules and consequently unable to take medicine as prescribed. Almost 50% of the population is affected by such problem, resulting in the high incidence of non compliance and ineffective therapy. Most pharmaceutical forms for oral administration are formulated for direct ingestion, or for chewing, or for p...

Taste masked microspheres of ornidazole were prepared using amino alkyl methacrylate copolymers (Eudragit E-100) by solvent evaporation technique. Taste assessment of these microspheres was done by both spectrophotometric taste evaluation technique and panel testing. Compressed tablets of taste masked ornidazole microspheres which rapidly disintegrated in the oral cavity were prepared using mic...

The aim of this study was to prepare, using taste masked granules, rapidly disintegrating tablets of chlorpheniramine maleate, a bitter drug. The taste masked granules were prepared using aminoalkyl methacrylate copolymers (Eudragit E-100) by the extrusion method. In vitro release profile obtained at pH 6.8 indicate that perceivable amount of drug will not be released in saliva while high perce...