T-regulatory cells (T(regs)) are a rare lymphocyte subtype that shows promise for treating infectious disease, allergy, graft-versus-host disease, autoimmunity, and asthma. Clinical applications of T(regs) have not been fully realized because standard methods of expansion ex vivo produce heterogeneous progeny consisting of mixed populations of CD4 + T cells. Heterogeneous progeny are risky for ...

Growth and egg production data from F2 layer chickens produced from a mating of MHC-heterozygous B15B44 sires to B15B44 and B15B43 dams were analyzed for associations with the level of the individual's genomic heterozygosity and dam MHC. The F1 sires and dams were produced from mating of birds from two genetically distinct, highly inbred lines. Genomic heterozygosity (expressed as composite ban...

Hybrid breeding, by taking advantage of heterosis, brings about many superior properties to the F1 progeny. However, some properties, such as increased plant height, are not desirable for agronomic purposes. To specifically counter the height increase associated with hybrid progeny, we employed an Arabidopsis model and tested a trans-activation system for specifically expressing a mutated GAI g...

Retinal stem cells (RSCs) are present in the ciliary margin of the adult human eye and can give rise to all retinal cell types. Here we show that modulation of retinal transcription factor gene expression in human RSCs greatly enriches photoreceptor progeny, and that strong enrichment was obtained with the combined transduction of OTX2 and CRX together with the modulation of CHX10. When these g...

Introduction CR-39 detectors are widely used for Radon and progeny measurement in the air. In this paper, using the Monte Carlo simulation, the possibility of using the CR-39 for direct measurement of Radon and progeny in water is investigated. Materials and Methods Assuming the random position and angle of alpha particle emitted by Radon and progeny, alpha energy and angular spectrum that arri...

Data from a two-breed group diallel experiment involving double-muscled (DM) and normal (N) cattle were analyzed to evaluate the importance of heterosis, maternal and direct effects for reproduction and growth traits. The DM cattle were from a composite of primarily Angus, Charolais, Galloway and Hereford breeds, and N cattle were crossbred cattle with at least 50% Hereford breeding. The data c...

Abstract The dearth of individual performance records derived from an extensively driven production system coupled with the impracticality utilizing reproductive technologies makes commercial genetic improvement challenging in small ruminants. We collaborated five producers throughout California to assess how electronic ID (EID) and testing could inform ram selection. Our objective was determin...

Validation of economic indexes under a controlled experimental environment, can aid in their acceptance and use as breeding tools to increase herd profitability. The objective of this study was to compare intake, growth and carcass traits in bull and steer progeny of high and low ranking sires, for genetic merit in an economic index. The Beef Carcass Index (BCI; expressed in euro (€) and based ...

A software tool was developed for the stochastic simulation of multiple traits and uses sequential culling for the different traits. It selects superior progeny and, at present, can calculate genetic gain from the backward selection of parent clones based on progeny performance, crossing those parent clones, and forwards selection among the progeny. Key information input to the program includes...