Background: The purpose of this study was investigate the dose proportionality of a novel, oncedaily, controlled-release formulation of hydromorphone that utilizes the OROS® Push-PullTM osmotic pump technology. Methods: In an open-label, four-way, crossover study, 32 healthy volunteers were randomized to receive a single dose of OROS® hydromorphone 8, 16, 32, and 64 mg, with a 7-day washout per...

Regeneration is deemed as the enabler for societies and nations to transform them from industrial age to knowledge. In this regard, knowledge intensive regeneration is one of the latest models, called as New Century Cities (NCC) to make progress and ultimately achieve the transformation towards knowledge societies, which have the features and characteristics of sustainable communities. However,...

Sustainable food production system is the key to sustainable development especially for hill communities where agriculture is the mainstay of economy. History shows that human societies that can protect their livelihood-based natural resources are able to sustain themselves. So even today we find several indigenous communities obtaining sustained and adequate income/returns from their agricultu...

the backwardness of the countryside is most important issues of developing countries. the result of this study, based on descriptive - analysis studies, shows that revive traditional arts and crafts with much charm with planning and organizing on development stimulus projects, can direct influence on the villager’s empowerment. of course, the existence of such attractions, itself, without provi...

Sustainable Development (SD) is a global role model that claims to function as a general orientation for shaping societal processes, i.e., local, regional, national and international development. This is in line with the Brundtland and justice-oriented understanding of the term. It is understood as a role model and sometimes also interpreted as a regulative ideal. However, it does not state how...