background: radiotherapy is the main modality of cancer treatment. there are many chemical radioprotectors which unfortunately have lethal or toxic effect. therefore the search is on to find out natural plant based radioprotectors. a well known medicinal plant,which is more acceptable to the body, tinospora cordifolia, was tested in animal tissues against gamma radiations. radioprotective effec...

PRE-084, a selective sigma receptor agonist, exhibited an antidepressant-like effect in the forced swim test (FST) in Albino Swiss and C57BL/6J mice. This effect was counteracted by BD 1047 (5 and 10 mg/kg) but not by SM-21 (3 and 10 mg/kg), which are sigma(1)- and sigma(2)-receptor antagonists, respectively. The results indicated that PRE-084 has an antidepressant-like effect in C57BL/6J and, ...

A 14-day subchronic genotoxicity of Nimesulide was evaluated by employing mouse bone marrow chromosomal aberration test. The Nimesulide administered orally for 2 weeks at the rate of 1.5, 2.5, 5 mg/kg body weight in swiss albino mice. The results show decreased mitotic activity in all groups of Nimesulide treatments. Similar results concerning the chromosomal aberrations revealed in all treated...

the aim of the present study was to evaluate vitamin c (vc) as a potent natural antioxidant to mitigate the genotoxic effects of arsenic trioxide and sodium fluoride in swiss albino mice in vivo. the study was divided into eight groups consisting of control treated with normal saline (group i), group ii, iii, iv, v, vi, vii and the vc group with only vitamin c (500 mg/kgbw). arsenic trioxide (4...

The effect of coccoid forms of a vaculating cytotoxin A positive Helicobacter pylori strain on Mus musculus (Swiss mice) and Rattus norvegicus (Albino rats) was studied. Two groups of Swiss mice and Albino rats were used. The first group of mice and rats was orally inoculated with coccoid forms of Helicobacter pylori, whereas, the second group of mice and rats were untreated and used as a contr...

The aim of the present study was to evaluate Vitamin C (VC) as a potent natural antioxidant to mitigate the genotoxic effects of Arsenic trioxide and sodium fluoride in Swiss albino mice in vivo. The study was divided into eight groups consisting of control treated with normal saline (Group I), Group II, III, IV, V, VI, VII and the VC group with only Vitamin C (500 mg/kgbw). Arsenic trioxide (4...

Background: This study was carried out to observe the radioprotective effects of Rosemarinus officinalis leaves extract (ROE) against radiation-induced histopathological alterations in liver of mice. Materials and Methods: Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of ROE to study the qualitative and quantitative alt...

Swiss Albino Mice........................................................... Inbred Mice................................................................ Hamsters................................................................. Squirrel Monkeys ......................................................... EFFECr ON RETENTION OF BACTERIA IN LUNGS................................. EFFECT ON LACTIC DEHY...

background: synthetic radio-protective agents like aminothiols are toxic and fda approved agent amifostine is no exception. some ayurvedic herbs have shown radioprotective potential. this study was carried out to test and compare the radioprotective potential of curcuma longa (cl) tinospora cordifolia (tc), zizyphus mauritiana (zm) and ocimum sanctum (os) against 2gy gamma irradiation in swiss ...