A key next step in synthetic biology is to combine simple circuits into higher-order systems. In this work, we expanded our synthetic riboregulation platform into a genetic switchboard that independently controls the expression of multiple genes in parallel. First, we designed and characterized riboregulator variants to complete the foundation of the genetic switchboard; then we constructed the...

There is an increasing demand for sharing documents for process integration among organizations. Web services technology has recently been widely proposed and gradually adopted as a platform for supporting such an integration. There are no holistic solutions thus far that are able to tackle the various protection issues, specifically regarding the security and privacy protection requirements in...

oad the heat-shock protein Hsp70 with a peptide from a tumor-specific antigen, then inject it into a mouse bearing a tumor with the same antigen, and the mouse will mount a vigorous immune response that can significantly reduce tumor progression. The result is promising, but how does it work? Studying human Hsp70, Becker et al. (page 1277) now show that the cell surface protein CD40 binds speci...

This paper discusses the challenges that arise when large speech corpora receive an ever-broadening range of diverse and distinct annotations. Two case studies of this process are presented: the Switchboard Corpus of telephone conversations and the TDT2 corpus of broadcast news. Switchboard has undergone two independent transcriptions and various types of additional annotation, all carried out ...

This paper describes a recently completed common resource for the study of spoken discourse, the NXT-format Switchboard Corpus. Switchboard is a long-standing corpus of telephone conversations (Godfrey et al., 1992). We have brought together transcriptions with existing annotations for syntax, disfluency, speech acts, animacy, information status, coreference, and prosody; along with substantial...