Syndactyly type I is an autosomal dominant condition with complete or partial webbing between the third and fourth fingers or the second and third toes or both. We report here a previously undescribed phenotype of severe mesoaxial syndactyly and synostosis in patients born to affected parents. The characteristic features of these severe cases are (1) complete syndactyly and synostosis of the th...

OBJECTIVE To assess and report clinical data from patients with syndactyly. METHODS A retrospective review of 47 patients treated between April 2002 and April 2012. RESULTS Among the 47 analyzed patients, 33 (70%) were male and 14 (30%) female. The total number of syndactylies was 116. The right hand was affected in 19 patients (40%), the left hand in 12 (24%) and 31 (36%) were bilaterally ...

The presence of 2 distinct populations of somatic or germline cells within a single individual harboring different genotypes is termed mosaicism. Recent reports suggest that parental mosaicism is involved in the heritability of type 1 Timothy syndrome (TS1), an extremely rare and life-threatening multisystem disorder characterized by severe QT interval prolongation, syndactyly, and several othe...

Apert syndrome (AS) is a rare type of congenital craniofacial dysmorphic and severe syndactyly the hands feet. Fibroblast growth factor receptor (FGFR) gene mutations are suspect to be involved in this anomaly. The distinct features craniosynostosis-a condition premature closure skull's sutures-, midface hypoplasia-an incomplete development middle face-, syndactyly-webbed fingers or toes-. anor...

BACKGROUND Syndactyly or webbed fingers is one of the most common congenital malformations of the upper extremities, but it comprises few new cases annually. The purpose of treatment is to enhance hand function. METHOD The article is based on current text books and literature searches in PubMed as well as the authors' clinical experience within this field. RESULTS The purpose of surgical tr...

Syndactyly and polydactyly-respectively characterized by fused and supernumerary digits-are among the most common congenital limb malformations, with syndactyly presenting at an estimated incidence of 1 in 2,000-3,000 live births and polydactyly at a frequency of 1 in approximately 700-1,000 live births. Despite their relatively regular manifestation in the clinic, the etiologies of syndactyly ...

W ebbing of the digits, or syndactyly, is not caused by the fingers sticking together in the womb; rather, it is caused by failure, during the sixth to eighth weeks of intrauterine life, of the usual longitudinal interdigital necrosis that normally separates the fingers. This " webbing " is the most common abnormality of the newborn hand. It happens either as an isolated anomaly or as part of a...

Abstract Aim Syndactyly of the foot is a common congenital abnormality, with an estimated prevalence 1 in 2,000. While thought to be more than hand syndactyly, there considerably less discussion syndactyly literature. We describe our operative approach and postoperative technique for splinting silicone moulds reduce webcreep complication. sought further characterise nature of, outcomes for, cas...

Preaxial polydactyly of the hand is more common than postaxial polydactyly and postaxial polydactyly of the foot is more common than preaxial in white patients. Syndactyly is commonly regarded as next in frequency among the congenital hand deformities. Preaxial polydactyly of the feet and hands and polydactyly type A and B with syndactyly in the same individual is a rare condition. In this work...