BACKGROUND The independent skeletal effect of thyrotropin (thyroid stimulating hormone, TSH) has been suggested in animal studies. However, clinical data on the association between bone loss and variations in TSH levels is inconsistent. This study aimed to investigate the relationship between TSH levels and bone mineral density (BMD). METHODS We conducted a cross-sectional study with 37,431 s...

This work was presented in part at the 53rd Annual Meeting of The American Thyroid Association, Cleveland, Ohio, 7-10 September 1977. Dr. Larsen is an Investigator of the Howard Hughes Medical Institute. Received for publication 29 August 1977 and in revised form 11 January 1978. well with both the change in TSH and the nuclear occupancy, suggesting a linear relationship between the integrated ...

UNLABELLED Elevated thyroid-stimulating hormone (TSH) was discovered by routine neonatal screening in a newborn with no clinical symptoms. Thyroid function tests were repeated and confirmed a high TSH value but normal total thyroxine (T4) and triiodothyronine (T3). However, the mother also had elevated serum TSH with normal levels of T4 and T3. The results suggested a transmitted maternal inter...

UNLABELLED BACKGROUND AND RATIONALE FOR THE STUDY: To investigate thyroid function in patients with acute-on-chronic liver failure (ACLF) caused by hepatitis B virus infection and to determine whether thyroid hormone levels can be used as prognostic markers for assessing severity and prognosis of ACLF patients. We enrolled 75 patients with ACLF and70 patients with chronic hepatitis B (CHB). Con...

Iopanoic acid has been shown to block thyroxine (T4)-5'-monodeiodination in rat anterior pituitary in vitro. To test the hypothesis that the acute decrease in thyrotropin (TSH) after infusion of T4 into hypothyroid rats requires intrapituitary T4 to 3,5,3'-triiodothyroxine (T3) conversion, the effect of iopanoic acid treatment on the generation of nuclear T3 from intrapituitary conversion and t...

The placenta may be involved in the regulation of the maternal thyroid function during pregnancy. As human chorionic gonadotropin (hCG) is a primary protein from the placenta, we examined the thyrotropic activity of hCG and its derivatives using tissue culture and monolayer cell culture of human thyroid glands. The TSH receptor preparation was made from thyroid tissues, and its binding affinity...

CONTEXT The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4. DESIGN Ra...

Objectives – To find the effect Of TSH suppression therapy on levels of TSH, T4 and T3 in hypothyroidism. Methods The study comprised of 40 subjects, classified into 2 groups each, with 20 subjects. Group I – 20 (Healthy individuals) controls aged between 20 – 45 years with euthyroid status. Group II20 Hypothyroid subjects with suppressed levels of TSH aged between 20 to 45 years. The parameter...