In an attempt to define the requirement of T8, T4, and T3 surface molecules in functional interactions occurring between human cytolytic T lymphocytes (CTL) and specific target cells, we have analyzed a large number of CTL clones derived from primary mixed lymphocyte culture (MLC) T cell populations for their susceptibility to inhibition by monoclonal antibodies (mAb) directed against these sur...

We used dual laser two-color flow cytometry to compare the expression of surface markers associated with activation and with differentiation in lung and peripheral blood T lymphocytes from normal subjects. T cell subsets, defined based on their reactivity with monoclonal antibodies (MAb) OKT3, OKT4, and OKT8, were analyzed for expression of activation antigens as detected by MAbs to the interle...

Epithelial-mesenchymal transition (EMT) in epithelial cells has been indicated as an important component of neoplastic transformation although, the genetic mechanism involved in this process has not been defined. The aim of this study was to evaluate the expression of different genes related to EMT such as E-cadherin, TGFbeta1, TGFbeta2, h-RAS, TWIST1, SNAIL2, SMAD5, FN1, CEACAM1 and JAG1 using...

Phase diagrams of the two-dimensional one-band t-t8 Hubbard model are obtained within the two-patch and temperature-cutoff many-patch renormalization group approaches. At small t8 and at van Hove band fillings antiferromagnetism dominates, while with increasing t8 or changing filling antiferromagnetism is replaced by d-wave superconductivity. Near t85t/2 and close to van Hove band fillings the ...

We consider d=10 N=1 supersymmetry algebra with maximal number of tensor charges Z and introduce a class of orbits of Z, invariant w.r.t. the T8 subgroup of massless particles’ little group T8 ⋉ SO(8). For that class of orbits we classify all possible orbits and little groups, which appear to be semidirect products of T8 ⋉ SO(k1) × ...SO(kn) form, with k1 + ...kn = 8, where compact factor is sp...

We consider d=10 N=1 supersymmetry algebra with maximal number of tensor charges Z and introduce a class of orbits of Z, invariant w.r.t. the T8 subgroup of massless particles’ little group T8 ⋉ SO(8). For that class of orbits we classify all possible orbits and little groups, which appear to be semidirect products of T8 ⋉ SO(k1) × ...SO(kn) form, with k1 + ... + kn = 8, where compact factor is...

Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells demonstrated substantial proliferation. These studies suggest that T8+ cells recognize signals from autologous non-T cells, but require an additional factor for the subsequent proliferative response. Sin...

The influence of T lymphocyte (T cell) subsets on the proliferation of the blood neutrophilic, macrophagic, and eosinophilic cluster and colony (aggregate) forming cells (CFC) was evaluated. The T cells and the CFC-enriched B-null cells (mononuclear cells depleted of monocytes and T cells) and null cells (B-null) cells depleted of B lymphocytes) were separated from the blood of normal individua...

Purified helper-inducer (T4+) and suppressor-cytotoxic (T8+) lymphocytes from eight patients with acquired immunodeficiency syndrome (AIDS) and eight healthy heterosexual donors were examined by limiting dilution analysis for their ability to be clonally expanded. It was demonstrated that viable T4+ and T8+ lymphocytes from patients with AIDS had markedly reduced proportions of clonable cells c...