INTRODUCTION Direct compression is the process of tabletting of a blend of ingredients, the compression mix, without a preliminary granulation or aggregation process. The compression mix contains the active pharmaceutical ingredient blended with one or more excipients.1 It has been estimated that less than 20 percent of pharmaceutical materials can be compressed directly into tablets. The rest ...

Orally disintegratingtablets (ODTs) comprising sustained release (SR) coated microparticles smallerthan 250 µm provide an appealing dosage form for patients with dysphagia,offering a superior mouthfeel and highly convenient route of administrationwithout the need water. SR coating requisite size(<200 µm) is incredibly challenging however utilisation theMicroCoat™ techno...

Sustained and controlled pellets are considered as one of the ideal dosage forms. Due to the large coverage area of pellets, loaded drugs can be absorbed completely in the body and bioavailability is improved correspondingly. Coated pellets-containing tablet is a special oral formulation consisting of various pellets with different release rate. Desired rate of drug release rate can be achieved...

Near infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode at-line evaluation. In this, the content of pharmaceutical active compound in the powder mi...

In case of Thiocarlidum (1) the thermoanalytical examination showed an endothermic transformation without loss of weight. This occured in samples recrystallized from cold polar solvents and the transformation proved to be non-reversible. The UV and IR spectra of the two samples differed characteristically and X-ray studies showed that the two modifications (in the following aand ßmodifications ...