OBJECTIVES Repeat transarterial chemoembolization (TACE) is a common intervention performed for hepatocellular carcinoma (HCC). The aim of this study was to identify predictors of the need for repeat TACE. METHODS Between 2008 and 2012, data on patient and tumour variables were collected for 262 patients treated with a first TACE procedure for HCC. The decision to perform repeat TACE procedur...

L-selectin mediates the initial tethering and subsequent rolling of leucocytes along luminal walls of inflamed venules. TACE [TNFalpha (tumour necrosis factor alpha)-converting enzyme] is responsible for cleaving the membrane-proximal extracellular domain of L-selectin (also known as shedding), which reduces the efficiency of leucocyte recruitment to sites of inflammation. Many reports have hig...

TNFα-converting enzyme (TACE/ADAM17) is a membrane-bound proteolytic enzyme with a diverse set of target molecules. Most importantly, TACE is indispensable for the release and activation of pro-TNFα and the ligands for epidermal growth factor receptor in vivo. Previous studies suggested that the overproduction of TACE is causally related to the pathogenesis of inflammatory diseases and cancers....

AIM To assess whether the effectiveness of a combination of transarterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) in the treatment of unresectable hepatocellular carcinoma (HCC) is superior to TACE alone a randomized controlled trial was performed. METHODS The effect of combination therapy on long-term survival rates and duration of hospitalization was evaluated in 5...

Introduction: Transarterial Chemoembolization (TACE) is one of the palliative treatments offered in patients staged Barcelona Clinic Liver Cancer (BCLC) B. TACE can lead to many complications, like decompensation liver, liver abscess, rupture, femoral artery pseudoaneurysm and gallbladder pathology. Methods: We report a case 58-year old gentleman, which developed extensive portal vein thrombosi...

Tumor necrosis factor alpha converting enzyme (TACE) is a sheddase overexpressed in cancers that generates cancer cell growth and survival factors, and is implicated in carcinogenesis and tumor growth. This indicates that TACE could be a potentially important cancer biomarker. Unexpectedly, TACE expression in cancer tissues does not correlate with cancer stage or invasiveness. Although TACE she...

Background: Outcome after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is highly variable. Aims: To identify factors affecting outcome after TACE forHCC. Methods: We conducted a retrospective analysis of HCC patients treated with TACE from January 2001 to December 2010 at the VA Medical Center, Gainesville, Florida using Fisher’s exact test and Mann Whitney U testfo...

Background and Aim: For intermediate HCC (hepatocellular carcinoma) with preserved liver function, Transarterial chemoembolization (TACE) is a standard therapy. Underlying disease reduces the net functionality of liver, hence post-TACE hepatic decompensation an important complication.Various pretreatment predictors have been studied to predict outcomes in HCC.Child-Pugh score ALBI are used asse...

TNF-alpha-converting enzyme (TACE, ADAM17) cleaves membrane-associated cytokines and receptors and thereby regulates inflammatory and immune events, as well as lung development and mucin production. For example, the TACE-mediated cleavage of the type II 75-kDa TNF receptor (TNFR2) generates a soluble TNF-binding protein that modulates TNF bioactivity. TACE is synthesized as a latent proenzyme t...

Transarterial chemoembolization (TACE) using doxorubicin-eluting beads (DEBs) have been introduced as a novel device which ensures more sustained and tumor-selective drug delivery and permanent embolization compared to conventional TACE with lipiodol. Studies highlighting the use of TACE with DEBs for the treatment of hepatocellular carcinoma (HCC) have shown similar or better results compared ...