Glycoproteins and glycopeptides are organic compounds that are composed of both polypeptide and carbohydrate chains bonded together. For many years glycoproteins and glycopeptides have been a subject of interest; however, recently they have aroused the interest of biochemists and biologists from a wide range of fields. This increased interest is partly due to the fact that glycoproteins were di...

Renata Soares1, Elisabete Pires1, André M. Almeida1,2, Romana Santos1,3, Ricardo Gomes1, Kamila Koči1, Catarina Ferraz Franco1 and Ana Varela Coelho1 1ITQB/Universidade Nova de Lisboa 2Instituto de Investigação Cientifica Tropical& Centro Interdisciplinar de Investigação em Sanidade Animal 3Unidade de Investigação em Ciências Orais e Biomédicas, Faculdade de Medicina Dentária/Universidade de Li...

■ Abstract This review is intended to serve as a practical guide for geneticists to current applications of tandem mass spectrometry to newborn screening. By making dried-blood spot analysis more sensitive, specific, reliable, and inclusive, tandem mass spectrometry has improved the newborn detection of inborn errors of metabolism. Its innate ability to detect and quantify multiple analytes fro...

Abbreviations: PTMs=post-translational modifi cations; PPIs=protein-protein interactions; SDS-PAGE= sodium dodecyl sulfate-polyacrylamide gel electrophoresis; 2D-PAGE=two-dimensional polyacrylamide gel electrophoresis; MS=mass spectrometry; ESI=electrospray ionization; MALDI=Matrix Assisted Laser Desorption Ionization; ESI-MS=electrospray ionization mass spectrometry; MALDI-MS=MALDI mass spectr...