Targeted alpha therapy is an emerging alternative for palliative of a wide range tumor types. Data from preclinicaland clinical research demonstrates high potential the selective killing cells and minimal toxicity to surroundinghealthy tissues. This article summarizes developmental stages alpha-targeted benchtop commercialization.It discusses fundamental properties, production pathways, microdo...

Semiconductor radiation detectors play an important role in radiation instrumentation. They have many advantages due to their small size, outstanding energy resolution in nuclear spectroscopy, easy pixilation for high spatial resolution and ability of integration with readout electronics. Advancement in microelectronic industry made silicon one of the most popular material for radiation detecto...

Boron neutron capture therapy (BNCT) is a form of chemically targeted radiotherapy that utilises the high neutron capture cross-section of boron-10 isotope to achieve a preferential dose increase in the tumour. The BNCT dosimetry poses a special challenge as the radiation dose absorbed by the irradiated tissues consists of several dose components with different relative biological effectiveness...

A brief overview is provided of the history of the development of internal dose methods for use in nuclear medicine. Basic methods of internal dosimetry and the systems that have been developed for use in nuclear medicine are described. The development of the MIRD system and the International Radiopharmaceutical Dosimetry Symposium series is outlined. The evolution of models and tools for calcu...

The field of microdosimetry is the study of those physical characteristics of energy transfers other than dose that produce variations in biological consequences of exposures to radiation. Historically, this area developed primarily from a need to understand and quantify the differences in human responses to different types of radiation, in particular the variations in late complications for th...

The objective of microdosimetry was, and still is, to identify physical descriptions of the initial physical processes of ionising radiation interacting with biological matter which correlate with observed radiobiological effects with a view to improve the understanding of radiobiological mechanisms and effects. The introduction of therapy with particles starting with fast neutrons followed by ...

background: image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. objectives: this study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in iran. methods: in this study, the most important medical datab...

The first results obtained using a SOI device for microdosimetry applications are presented. Microbeam and broadbeam spectroscopy methods are used for determining minority carrier lifetime and radiation damage constants. A spectroscopy model is presented which includes the majority of effects that impact spectral resolution. Charge collection statistics were found to substantially affect spectr...

Introduction: NanOx is a theoretical framework developed to predict cell survival ionizing radiation in the context of radiotherapy. Based on statistical physics, takes stochastic nature at different spatial scales fully into account. It extends concepts from microdosimetry nanodosimetry, and considers as well primary oxidative stress. This article presents detail general formalism behind NanOx...