alpha(1)-Adrenergic signaling in cardiac myocytes activates the skeletal muscle alpha-actin gene through an MCAT cis-element, the binding site of the transcriptional enhancer factor-1 (TEF-1) family of transcription factors. TEF-1 accounts for more than 85% of the MCAT binding activity in neonatal rat cardiac myocytes. Other TEF-1 family members account for the rest. Although TEF-1 itself has l...

Gestational exposure to a high-fat diet (HFD) stimulates the differentiation of orexigenic peptide-expressing neurons in the hypothalamus of offspring. To examine possible mechanisms that mediate this phenomenon, this study investigated the transcriptional factor, transcription enhancer factor-1 (TEF), and co-activator, Yes-associated protein (YAP), which when inactivated stimulate neuronal dif...

The purpose of this study was to compare antioxidative potential of methanolic extracts of three tef grain (Eragrostis tef) varieties (white, brown and red tef) and their respective injera (pancakelike, soft, sour, circular flatbread and a staple food for majority of Ethiopians) and enriched one with fenugreek. Injera was prepared from dough fermented for 18 hours and 72 hours. The level of IC5...

Transcriptional activity of the smooth muscle (SM) α-actin gene is differentially regulated in SM vs. non-SM cells. Contained within the rat SM α-actin promoter are two MCAT motifs, binding sites for transcription enhancer factor 1 (TEF-1) transcriptional factors implicated in the regulation of many muscle-specific genes. Transfections of SM α-actin promoter-CAT constructs containing wild-type ...

Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, indicating its etiologically heterogeneous nature. Recent advances in genotyping technology and in ...

MCAT elements are located in the promoter-enhancer regions of cardiac, smooth, and skeletal muscle-specific genes including cardiac troponin T, beta-myosin heavy chain, smooth muscle alpha-actin, and skeletal alpha-actin, and play a key role in the regulation of these genes during muscle development and disease. The binding factors of MCAT elements are members of the transcriptional enhancer fa...

The thermic effect of food (TEF) declines with advancing age in adult humans but is enhanced in the habitually exercising state. The responsiveness of the sympathetic nervous system (SNS) has been implicated in these differences in TEF. We tested the hypotheses that 1) the reduction in TEF with aging is associated with an attenuated SNS response to acute energy intake; and 2) the greater TEF ob...

OBJECTIVE The aim of the present study was to evaluate the results of surgical treatment in patients with simultaneous occurrence of postintubation tracheal stenosis (TS) and tracheoesophageal fistula (TEF). METHODS In the group of 51 patients with postcannulation tracheal stenosis who underwent segmental resection, TEF was identified simultaneously in five (10%) of them. The mean age of the ...

OBJECTIVE To determine if the presence of a tracheo-esophageal fistula (TEF) alters outcome following laryngeal cleft repair. DESIGN A retrospective review of patients diagnosed and treated for laryngeal clefts, with a minimum follow-up period of 1 year. SETTING An academic tertiary care children's hospital. PATIENTS Twenty-five pediatric patients diagnosed and surgically treated for lary...

BACKGROUND Thyrotroph embryonic factor (TEF), a member of the PAR bZIP family of transcriptional regulators, has been involved in neurotransmitter homeostasis, amino acid metabolism, and regulation of apoptotic proteins. In spite of its relevance, nothing is known about the regulation of TEF. PRINCIPAL FINDINGS p53-dependent genotoxic agents have been shown to be much more harmful for PAR bZI...