conclusions since telomerase is expressed in 90% of cancer cells, its inhibition can be considered as a goal of cancer treatment. results about 90% of cancers need a high level of this enzyme to continue cell multiplication. since this enzyme set is absent in normal cells, or present at a very low level, use of telomerase inhibitors cannot have significant effects on normal cells. evidence acqu...

background: limited resources for adult stem cells necessitate their in vitro culture prior to clinical use. investigating mitochondrial dna (mtdna) and telomere shortening has proved to be important indications of stem cell validity. this study was designed to investigate these indicators in multiple passages of three adult stem cell lines which were produced in our stem cell laboratory. metho...

introduction: the telomeric dna together with its associated  proteins protects the chromosome ends from degradation or aberrant recombination. telomerase and telomere are closely associated with  development of cancers. in this study we aim to investigate the significance of telomerase activity (ta) and telomere length (tl) in patients with acute promyelocytic leukemia (apl). methods: peripher...

objective(s): to investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. in addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (tips) using in silico studies. materials and methods: human adipose derived stem cells (hascs) were studied under treatments with 2.5 µm/ml cinnamaldehyde, 0....

Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men. ...

Objective(s): To investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. In addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (TIPs) using in silico studies. Materials and Methods: Human adipose derived stem cells (hASCs) were studied under treatments with 2.5 µM/ml cinnamaldehyde, 0....

Telomere length and stability is a biomarker of aging, stress, and cancer. Shortening of telomeres and high level of DNA damages are known to be associated with aging. Telomere shortening normally occurs during cell division in most cells and when telomeres reach a critically short length, DNA damage signaling and cellular senescence can be triggered. The induction of an adaptive response by sp...

introduction: telomeres are repetitive sequences of ttaggg section that find at two ends of eukaryotic chromosomes and they shield chromosome ends. telomere shortening in patients with myocardial infarction has been reported. shelterin complex's role is essential in telomere length regulation. telomeric repeat binding factors 1 and 2 (trf1 and trf2) are the most important sheltrein complex...

Introduction: Telomeres are repetitive sequences of TTAGGG section that find at two ends of eukaryotic chromosomes and they shield chromosome ends. Telomere shortening in patients with myocardial infarction has been reported. Shelterin complex's role is essential in telomere length regulation. Telomeric repeat binding factors 1 and 2 (TRF1 and TRF2) are the most important sheltrein complex pr...