background epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. up to now, several diagnostic approaches have been processed to determine the epileptic focus. objectives the aim of this study was to discover whether proton-mr-spectroscopic imaging (mrsi) aids in the diagnosis of temporal lobe epilepsy in conjunction with classical ele...

introduction: transforming growth factor-beta 1 (tgf-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of ischemic stroke (is), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509c/t tgf-β1 gene polymorphism has been found to be assoc...

in the last century, neural stem cells are used in a lot of studies for basic and therapeutic investigations. several sources are identified for neural stem cells including embryonic, fetal and adult stem cells. although most of studies have focused in embryonic as well as fetal cells due to their capacity to generate progenies, these cells have some problems such as immunological, availability...

background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

introduction : shared neuropathology hypothesis in schizophrenia and temporal lobe epilepsy has been introduced long term ago. similar neuropathology leads to the analogous clinical features like neuropsychological features as an example. the aim of this study was to examine this hypothesis by the means of comparing neuropsychological functions in these two patient groups. method : present stud...

background and objective: temporal lobe epilepsy (tle) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. this study was designed to assess the protective effe...

background: mesial temporal lobe epilepsy (tle) is a remediable epileptic syndrome. about 40% of patients continue to have seizures after standard temporal lobectomy. it has been suggested that some of these patients could actually suffer from a more complex epileptogenic network. because a few papers have been dedicated to this topic, we decided to write an article updating this theme. methods...

background epilepsy is a chronic neurological disease with the prevalence of around one percent. despite the introductions of several anti-epileptic drugs, around 1/3 of epileptic patients are resistant to the anti-epileptic medications. objectives considering the evidence regarding the anti-oxidant action of vitamin e and its beneficiary effect in the treatment of epilepsy, we investigated the...

introduction: kainic acid (ka) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (tle). according to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (se) induced by ka. this study aimed to quantitatively evaluate changes...