In 1771, Guillaume Pellier de Quengsy,1 an ophthalmologist, proposed for the first time the possibility of substituting opacifie corneal tissue by “an artificial cornea”. The proposal was for transparent glass plates to substitute the opaque cornea in order to enhance the transparency of optic media. Improvements in topical and systemic immunosuppression and limbus transplant techniques for tre...

OBJECTIVE To develop a laboratory model to study intracorneal keratoprosthesis implantation. METHODS A combination microkeratome and artificial anterior chamber system was used to create a hinged lamellar keratectomy on 13 human corneas. After reflecting the flap, the posterior stroma was trephined at either 2.5 or 3.0 mm. A model keratoprosthesis was positioned in the bed. The flap was sutur...

PURPOSE To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro). METHODS In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT) evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interfac...

BACKGROUND The purpose of this study was to assess whether the resolution offered by two different, recently commercially available high-resolution, spectral-domain anterior segment optical coherence tomography (AS-OCT) instruments allows for detailed anatomic characterization of the critical device-donor cornea interface in eyes implanted with the Boston type I permanent keratoprosthesis. ME...

PURPOSE To conduct a cost-utility analysis and determine the cost-effectiveness of the Boston Keratoprosthesis (Boston Kpro). DESIGN Retrospective cohort study. METHODS setting: The Massachusetts Eye and Ear Infirmary corneal service. patients: Inclusion required a minimum 2-year follow-up. Patients with autoimmune diseases and chemical burns were excluded. Eighty-two patients were included...

Objective To describe a case of severe chemical burn treated with novel Boston type I keratoprosthesis (B1-KPro) technique. Methods We present the 25-year-old woman poor light perception in both eyes who had bilateral caustic soda 3 months earlier. She underwent several amniotic membrane implants and subconjunctival triamcinolone injections without significant improvement. decided to perform tw...

OBJECTIVE To develop a newly designed double-fixed keratoprosthesis (Seoul-type keratoprosthesis [S-KPro]) and to assess its mechanical stability and biocompatibility. METHODS Twenty-five rabbits were divided into 4 groups by fixation technique, amniotic membrane (AM) implantation, and skirt material. The eyes were studied with the use of slitlamp, light, and electron microscopy. Stress testi...

PURPOSE To describe the clinical course of a patient with a Boston Keratoprosthesis type I who developed a localized posterior pole retinal detachment secondary to a macular hole. OBSERVATIONS A 73-year-old patient with a Boston Keratoprosthesis developed a localized posterior pole retinal detachment secondary to a macular hole. The retinal detachment was repaired with a 23-gauge pars plana v...

We report the histopathology of epithelial overgrowth in the Boston type I keratoprosthesis. The epithelium shows an inconsistent number of layers and basement membrane and goblet cells are absent. Epithelialization of the keratoprosthesis optic would have multiple advantages, but the limitation of vision makes tolerating the overgrowth difficult.