Objectives: To assess the extent to which teratogenic drugs are prescribed during pregnancy and to investigate. the feasibility of an alert system at the point of prescription, in order to improve drug safety during pregnancy. Methods: We establish a reference list of teratogenic drugs by merging lists of teratogenic drugs published in the literature, extract drug prescriptions to pregnant wome...

The zebrafish model is an attractive candidate for screening of developmental toxicity during early drug development. Antiepileptic drugs (AEDs) arouse concern for the risk of teratogenicity, but the data are limited. In this study, we evaluated the teratogenic potential of seven AEDs (carbamazepine (CBZ), ethosuximide (ETX), valproic acid (VPN), lamotrigine (LMT), lacosamide (LCM), levetiracet...

In normal development, each gene correctly expresses under temporal and spatial regulation. Teratogenic agents among environmental contaminants induce aberrated gene expression and consequently lead to congenital malformations. Therefore, it is urgent to identify molecular markers for the detection of teratogenic agents' effects.We analyzed mouse 39 hox gene expression in teratogenic factor exp...

metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. there are controversy aspects about its teratogenicity. a teratogenic agent can alter morphology or subsequent function of the fetus. the aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by metronidazole usin...

This investigation began as an attempt to protect chick embryos from the teratogenic effects of hypoxia by means of exogenously applied calcium pantothenate. The attempt was not only a failure, but it appeared that the compound alone was highly teratogenic. Since it was disturbing to consider that a vitamin, in low dosage, was teratogenic, the phenomenon was studied further by injecting equival...