There are errors in the Funding section. The correct funding information is as follows: The present study was funded by the Wellcome Trust and the Medical Research Council Programme (MRC Ref: G1002231 awarded to BJE, JWD, TWR, Wellcome Trust Ref: 093875/Z/ 10/Z), and the R24 Alcohol Research Resource Award grant (R24 AA015512) from NIAAA. The funders had no role in study design, data collection...

Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-alpha (TNF-alpha) with the monoclonal antibody R24 (MoAb R24) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R24 to recrui...

Association of gangliosides with specific proteins in the central nervous system was examined by co-immunoprecipitation with anti-ganglioside antibody. Protein kinase activity was detected in precipitates with monoclonal antibody to ganglioside GD3 (R24) from membranal fraction of rat brain. Using in vitro kinase assay, several phosphorylated proteins of 40, 53, 56, and 80 kDa were isolated by ...

The effects of goal-directed fluid therapy, with lactated Ringer's (LR) and 6% hydroxyethyl starch (HES) solution, on hemorrhagic shock dogs are unknown. We aimed to determine the optimal LR: HES ratio for the resuscitation of hemorrhagic shock dogs. Hemorrhagic shock was induced in 40 ventilated dogs by drawing an estimated 60% blood volume. The animals were randomly divided into five groups (...

Authors Affiliations: Departments of Neurology and Radiology, Sloan Kettering Institute Molecular Pharmacology and Chemistry Program.Cyclotron and Radiochemistry Core Facility, Department of Medicine, Laboratory of New Drug Development. Memorial Sloan-Kettering Cancer Center, New York, New York. 6 Departments of Medicine and Pharmacology, CINJ, RWJMS, UMDNJ, NJ Research funding: AstraZeneca and...

In this research announcement we outline the methods used in our recent proof that the Leech lattice is the unique densest lattice in R24. Complete details will appear elsewhere, but here we illustrate our techniques by applying them to the case of lattice packings in R2, and we discuss the obstacles that arise in higher dimensions.

Alterations in nutritional status affect hepatic cytochrome P450 levels. Since cytochromes P450 participate in the metabolism of arachidonic acid, we hypothesized that changes in liver P450 arachidonic acid metabolism occur during fasting and refeeding. Male Fisher 344 rats were either fed, fasted 48 hr (F48), fasted 48 hr and then refed 6 hr (F48/R6), or fasted 48 hr and then refed 24 hr (F48/...

This paper develops and estimates a dynamic model of individual’s and couples’ labor supply and saving decisions to analyze the effects of a recent pension reform in Chile. Chile has one of the longest-running nationwide private retirements accounts systems in the world, operating since 1980, and its pension system served as a model for many other countries. In 2008, Chile undertook a major ref...