the present work comprises the synthesis of one series of diarylmethane dyes containing one or more terminal methoxy substituents together with a variable tertiary amino group. the electronic absorption spectra of the dyes have been determined. as the conjugation of the terminal nitrogen atom improves in the sequence nmez > kairoline > julolidine, a progressive hypsochromic shift is observed

It now appears to be well established that the tertiary structure of a protein is determined primarily by its amino acid sequence. The principal support for this concept is the demonstration that several enzymes (particularly bovine pancreatic ribonuclease, egg white lysozyme, and Tska-Amylase A) spontaneously regain their native conformations after they have been unfolded and their disulfide b...

MolyMod kits can be used to model amino acids. Notice that the amino acid model does not lie flat, like Proteins fold up in a hierarchical manner....that is, in stages. Stretches of amino acids within the entire amino acid sequence of a protein (the primary structure) will spontaneously adopt one of several ordered structures (the secondary structure) which then folds into an overall energetica...

BACKGROUND This study aimed to evaluate the impact of diagnosis-related group (DRG) payments on health-care providers' behavior and the potential best course of action to make a profit under a DRG payment mechanism. METHODS This is a natural experiment study with a tertiary hospital-based dataset. Under a consecutive three-period (3 years) or 12-period (12 seasons) design, length of stay, med...

The retention behavior of primary, secondary and tertiary amines was studied using normal-phase-HPLC on silica, diol, and cyano stationary phases. Several classes of amines, including benzylamines, anilines, ephedrines, tryptamines, and azatryptamines were chromatographed using mixtures of hexane and ethoxynonafluorobutane with methylene chloride and methanol. Peak tailing, diminished selectivi...

The carboxylic ester hydrolases (CEHs) are enzymes that hydrolyze an ester bond to form a carboxylic acid and an alcohol. They are one of the enzyme groups that are most explored industrially for their applications in the food, flavor, pharmaceutical, organic synthesis, and detergent industries. We classified CEHs into families and clans according to their amino acid sequences (primary structur...

Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-order levels, an organization that guides our current understanding of their biological properties and evolutionary origins. Here, we reveal a structural organization distinct from this traditional hierarchy by statistical analysis of correlated evolution between amino acids. Applied to the S1A serin...

Albert Isidro-Llobet, Mercedes Álvarez, Fernando Albericio Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028Barcelona, Spain. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028Bar...

To obtain small membrane markers easily accessible to the charged groups of the cell surface, we prepared, from hemeundecapeptide (HUP), three derivatives that maintain the peroxidatic activity: the anionized hemeundecapeptide, Mr 1,963, estimated diameter 1.68 nm, pl 3.5, for the detection of basic groups; and both a cationized hemeundecapeptide containing predominantly tertiary amino groups, ...