Background: Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. More than 90% of men with epilepsy have abnormal semen analysis, including decreased sperm count, abnormal morphology, and impaired motility. The aim of this study was the assay of chronic treatment with melatonin during the latent phase and chronic phase of e...

BACKGROUND Ginger is a natural dietary component with antioxidant and anti-carcinogenic properties. This study was conducted to evaluate the prophylactic effect of ginger extract on ethanol-induced reproductive toxicity in male rats by measuring the total homocysteine (tHcy), trace elements, antioxidant enzymes activity including glutathione peroxidase, superoxide dismutase (SOD) and catalase, ...

Oxidative stress plays an important role as a mediator of damage produced by fructose metabolism. This work was designed to investigate the effect of diet supplemented with quinoa seeds on oxidative stress in plasma, heart, kidney, liver, spleen, lung, testis and pancreas of fructose administered rats. Fructose administration (310 g/kg fodder for 5 weeks) caused oxidative stress that was manife...

This study aimed to utilize whey protein nanoparticles (WPNPs) and zinc (Zn) loaded WPNPs protect against carbon tetrachloride (CCl 4 )-induced testicular damage in rats. Zn was on at three levels release determined different time intervals. Seventy male Wistar rats were divided into 7 groups treated orally for weeks as follows: the control group, CCl -treated group (0.5 ml/100 g b.w) twice a w...

welsh onion (allium fistulosum l.) is one of the important vegetable crops in china. however, the seeds of this crop are short-lived and their vitality tends to be easily lost in the course of storage. the present study was conducted to elucidate the effects of welsh onion seed priming with potassium nitrate (kno3) on seed vigor and on other such related mechanisms during twelve months of stora...

We suggest that varicocele leads to male factor infertility by a mechanism involving underperfusion of the testis, a shortfall in glucose supply to the tissue, decreased flux through the pentose phosphate pathway, lowering of the reduced nicotinamide-adenine dinucleotide phosphate/oxidized nicotinamide-adenine dinucleotide phosphate ratio and the supply of glutathione to the antioxidant systems...

Background The present study describes the susceptibility of prepubertal testis of mice to prooxidant induced oxidative impairments both under in vitro and in vivo exposure conditions. MaterialsAndMethods Following in vitro exposure to iron (5,10 and 25 M), oxidative response measured in terms of lipid peroxidation and hydroperoxide levels in testis of pre pubertal mice (4 wk) was more robust c...

This study aims to explore the protective effect of selenium (Se) on chronic zearalenone (ZEN)-induced reproductive system damage in male mice and the possible protective molecular mechanism against this. The chronic ZEN-induced injury mouse model was established with the continuous intragastric administration of 40 mg/kg body mass (B.M.) ZEN for 28 days. Then, interventions with different dose...

To asses whether prenatal exposure to lead induces testicular oxidative status at adulthood, pregnant Wistar rats were exposed to an ad libitum drinking water containing lead acetate at 0.05% and 0.15% respectively, throughout their pregnancy period. All the animals were allowed to deliver pups. Lead exposure was continued throughout the lactation period. Weaned pups were allowed to grow on nor...

Cisplatin is an effective chemotherapeutic drug used to treat many types of tumours. However, it may cause male reproductive toxicity. Gallic acid exhibits beneficial effects such as antioxidant, anti-inflammatory and antitumor. The current study investigated the gallic against testis epididymis toxicity induced by cisplatin. Male rats were divided into 4 groups follows (n = 7): Control, cispla...