To explore whether an environment of weightlessness will cause damage to the reproductive system of animals, we used the tail-suspension model to simulate microgravity, and investigated the effect of microgravity on the tissue structure and function of the testis in sexually mature male rats. Forty-eight male Wistar rats weighing 200-250 g were randomly assigned to three groups (N = 16 each): c...

This study aimed to utilize whey protein nanoparticles (WPNPs) and zinc (Zn) loaded WPNPs protect against carbon tetrachloride (CCl 4 )-induced testicular damage in rats. Zn was on at three levels release determined different time intervals. Seventy male Wistar rats were divided into 7 groups treated orally for weeks as follows: the control group, CCl -treated group (0.5 ml/100 g b.w) twice a w...

This study investigated the probable protective effects of resveratrol (RES), an antioxidant, against methotrexate- (MTX-) induced testis damage. Twenty-four male Sprague Dawley rats were randomly divided into four groups: control, RES, MTX, and MTX + RES groups. Rats were sacrificed at the end of the experiment. Plasma and tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD) and cat...

Objective: The aim of this study was to investigate the protective effect CAPE on oxidative stress and apoptosis against streptozotocin (STZ)-induced damage in rat testis after diabetes. Materials methods: rats were randomly divided into 4 groups: Control animals, animals given CAPE, STZ-induced diabetic CAPE. Diabetes induced by a single intraperitoneal injection STZ (55 mg/kg). Testicular exa...

The underlying primary damage to the testis caused by chemotherapeutic regimens during childhood is largely unknown. Xenografting of monkey testes was successfully applied in maturation of juvenile testis to the point of complete spermatogenesis. This allows us to manipulate developing primate testis without direct treatment of patients. This new model is validated establishing the effects of c...

The effect of endosulfan, an Organochlorine pesticide, on bluegill testes was studied. Endosulfan is aqua-toxic and has an immediate effect on fish and other aquatic life. In this experiment, we exposed the fish for 24-, 48-, 72-, 96-h, and 1- and 2-week periods. A second group of fish without exposure to endosulfan served as the control. The control testis appeared structurally normal. The sem...

BACKGROUND It is proved that testis is sensitive to electromagnetic field (EMF) and its damage results in infertility. Exposure to EMF induces reactive oxygen species production and affects on anti-oxidants defense mechanisms. Metallothionein (MT) is a name for a group of low molecular weight (6-7 kDa), sulfhydryl rich proteins. Expression of MT1 and MT2 genes in testis tissue after EMF exposur...

a:4:{s:9:"Objective";s:335:"There is some evidence that shows Matricaria chamomile (MC) plays an important role in ischemia-reperfusion. In the present study, a rat model of torsion/detorsion to investigate the effect of hydroalcoholic extract of MC on testis tissue damage was used. In adult rat testis, the oxidative stress (OS) induced by ischemia-reperfusion.";s:19:"MaterialsAndMethods";s:913...

objective(s): gentamicin is used for the treatment of gram-negative bacterial infections. however, gentamicin administration is limited because of nephrotoxicity. the aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. materials and methods: thirty two male wistar rats received gentamicin (100 mg/kg, ip), with or without cr...

Spermatogenic damage may occur after vasectomy, and the damage is pressure mediated, occurring when the occluded reproductive tract is unable to accommodate additional sperm produced by the testis. This study aimed to determine the long-term effect of vasectomy on spermatogenesis in humans and clarify how the balance between sperm production in the testis and sperm storage in or removal from th...