Protection to tetanus is often not optimal in developing countries due to incomplete vaccination schemes, or decreased efficacy of vaccination. In this study we investigated the immunological response to tetanus booster vaccination in school children living in a semi-urban or in a rural area of Gabon. Tetanus-specific total IgG as well as antibody subclasses of the IgG1, IgG2, IgG3 and IgG4 iso...

OBJECTIVE To study the human teratogenic potential of tetanus vaccination during pregnancy. METHODS Pair analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994. RESULTS Of 35 727 pregnant women who had babies without any defects in the s...

Tetanus is a neurological disorder caused by Clostridium tetani. Although vaccination has significantly reduced the incidence of tetanus worldwide, the occurrence of sporadic cases requires effective and timely treatment. In this study, we report the case of a 45-year-old man who had difficulty in swallowing and opening mouth. The patient had the history of a small puncture wound with a nail in...

of the clinical presentation of the disease. The diagnosis can be suspected but not confirmed in the emergency depart­ ment (ED). In addition to recognizing the clinical presentation of tetanus, EPs play a vital role in the prevention of the disease. Primary pediatric vaccination and regular decennial booster vaccination are the mainstays of disease prevention and sever­ ity modulation. Herd im...

Background and Aims: Despite the fact that neonatal tetanus has been eradicated all over the world, it is still a significant health problem in some developing countries. The disease can even result in death. This is a worrying problem but it can easily be prevented by vaccination of the mothers. Vaccinating every pregnant woman with, at least, one dose of tetanus toxoid would be an affordable ...

BACKGROUND Health care personnel (HCP) are at risk for exposure to and possible transmission of vaccine-preventable diseases. Maintenance of immunity is an essential prevention practice for HCP. We assessed the recent influenza, hepatitis B, and tetanus vaccination coverage among HCP in the United States. METHODS We analyzed data from the 2007 National Immunization Survey-Adult restricted to ...

The duration of protection after vaccination with reduced antigen content diphtheria, tetanus and acellular pertussis vaccines (Tdap) is not known. Long-term post-vaccination serological data will help to improve understanding of the duration of humoral immunity and guide vaccination policy for the timing of repeat dose administration. The persistence of antibodies to Tdap antigens was measured...

Current UK policy on immunisation for tetanus has changed in the light of evidence that five doses of vaccine probably provides sufficient protection as long as high-risk wounds are managed with tetanus immunoglobulin. This paper reviews the evidence base for tetanus immunisation policy in England and Wales: the epidemiology of tetanus, vaccination coverage and response to tetanus toxoid, and p...

Maternal immunization with tetanus toxoid (TT) is the most effective was to prevent neonatal tetanus. In Duhok, Iraq data indicate low vaccination coverage. This study assessed TT immunization status among 600 randomly selected pregnant women attending Azadi teaching hospital, Duhok for delivery, by both tetanus antibody seroprevalence and TT history. WHO criteria for protective levels were use...

This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and te...