Olfactomedin-1 (Olfm1; also known as noelin and pancortin) is a member of the olfactomedin domain-containing superfamily and a highly expressed neuronal glycoprotein important for nervous system development. It binds a number of secreted proteins and cell surface-bound receptors to induce cell signaling processes. Using a combined approach of x-ray crystallography, solution scattering, analytic...

Topological indices are numerical parameters of a graph which characterize its topology. In this paper the PI, Szeged and Zagreb group indices of the tetrameric 1,3–adamantane are computed.

The skin mucus IgM is an important molecule in the mucosal immune system of teleost skin. However, the transport mechanism associated with this molecule has yet to be clarified. In this study, we isolated a gene encoding a polymeric Ig receptor (pIgR) from a species of teleost fish, Takifugu rubripes (fugu). This gene is known to be an Ig transporter in the intestine of mammals. Our studies fur...

There is considerable current interest in the design of nonACHTUNGTRENNUNGproteinaceous quaternary structures with defined oligomeric states because these materials have potential as nanomaterial scaffolds, drug delivery tools and enzymatic platforms. We recently described a series of b-peptides, which are exemplified by the sequences of Zwit-1F and Acid-1Y (Figure 1A), that assemble into octam...

In this paper, we introduce the E-Banhatti Sombor index and modified their corresponding exponentials of a graph. Also compute these newly defined indices for wheel graphs, friendship tetrameric 1,3-adamantane honeycomb networks. Furthermore, establish some properties index.

Tuftsin, Thr-Lys-Pro-Arg (TKPR), is an immunostimulatory peptide with reported nervous system effects as well. We unexpectedly found that tuftsin and a higher affinity antagonist, TKPPR, bind selectively to neuropilin-1 and block vascular endothelial growth factor (VEGF) binding to that receptor. Dimeric and tetrameric forms of TKPPR had greatly increased affinity for neuropilin-1 based on comp...

Post-translational modifications are difficult to visualize in living cells and are conveniently analyzed using antibodies. Single-chain antibody fragments derived from alpacas and called nanobodies can be expressed and bind to the target antigenic sites in living cells. As a proof of concept, we generated and characterized nanobodies against the commonly used biomarker for DNA double strand br...

Address reprint requests to Dr. Weller, Beth Israel Hospital. Received for publication 23 June 1982 and in revised form 30 September 1982. termined from amino acid composition analysis for the tetrameric form of the enzyme. The specific functional activity of the purified arylsulfatase B was concentration and time dependent, compatible with its association or dissociation into subunit forms wit...