Some pentafluoropyridine derivatives have been synthesized by the reaction of pentafluoropyridine with appropriate C, S and N-nucleophile such as malononitrile, 1-methyl-tetrazole-5-thiol and piperazine. These reactions provided 4-substituted 2,3,5,6-tetrafluoropyridine derivatives in good yields. All the compounds were characterized using (1)H, (13)C and (19)F-NMR spectroscopy and X-ray crysta...

Different tetrazole derivatives containing isoxazole has been synthesized. 5-phenyl tetrazoles (1) was cyclized using sodium azide and ammonium chloride and benzonitrile. The 5-phenyl tetrazoles on treatment with acetic anhydride forms 5-phenyl 1-acetyl Tetrazole (2) which on reaction with different aromatic aldehydes forms chalcones (3ah).The chalcones further undergo cyclisation with hydroxyl...

Drawing the experience of 5-phenyl- and 5-pyridyltetrazoles, it was shown that classical nitration-reduction methods in combination with typical alkylation reactions tetrazole derivatives can be used to obtain multitopic polynuclear tetrazole-containing ligands. Methods for preparation a number previously undescribed derivatives, including those combining both pyridine rings molecule, have been...

High Energy Materials is a term that is used for explosives, propellants and pyrotechnics. Explosives are used for military applications. 5-Picrylamino-1,2,3,4-tetrazole(PAT) is an explosive substance. In this study the reactions of the 5-Picrylamino-1,2,3,4-tetrazole(PAT) with nanostructures of fullerene and boron nitride nano-cages in different conditions of temperature, with density function...

High Energy Materials is a term that is used for explosives, propellants and pyrotechnics. Explosives are used for military applications. 5-Picrylamino-1,2,3,4-tetrazole(PAT) is an explosive substance. In this study the reactions of the 5-Picrylamino-1,2,3,4-tetrazole(PAT) with nanostructures of fullerene and boron nitride nano-cages in different conditions of temperature, with density function...

A variety of novel tetrazole derivatives attached to the β-lactam ring was made utilizing heptanitrile in a reaction with generated azide-β-lactam derivatives, and these compounds were then studied using IR NMR spectroscopy. Biological testing showed that most final good antibacterial antifungal activity, particularly derivative (b3), which shown efficacy on par or even superior reference drugs...

An efficient method for the preparation of 5-substituted 1H-tetrazole derivatives is reported using MoO3-SiO2 as an efficient heterogeneous catalyst. This method has the advantages of high yields, simple methodology and easy work-up. This catalyst could be recycled very easily, which makes this methodology environmentally benign.

A series of tetrazole derivatives (3a-h) were synthesized and screened for antioxidant activity by nitric oxide free radical scavenging activity. All the synthesized compounds were structurally elucidated by spectral techniques such as IR, H NMR spectroscopy and mass spectrometry. The compounds 3b, 3d 3f and 3h exhibited promising antioxidant activities which were found to be comparable with st...

During this study the application of Natrolite zeolite was investigated as a solid acid catalyst for efficient preparation of 5substituted 1H-tetrazole derivatives. Excellent yields of products were obtained with a wide range of substrates. After completion of the reaction, the catalyst was recovered by filtration and reused several times with only a slight decrease of activity observed under t...