Background—Reoxygenation injury is a result of several complex events, including release of reactive oxygen species, protein kinase C (PKC) activation, and altered expression of transforming growth factor1 (TGF1). Nitric oxide (NO) generally protects tissues from reperfusion injury. Methods and Results—We examined the modulation of TGF1 expression and activity and PKC activation in cultured rat...

Runyan, Constance E., H. William Schnaper, and Anne-Christine Poncelet. Smad3 and PKC mediate TGF1-induced collagen I expression in human mesangial cells. Am J Physiol Renal Physiol 285: F413–F422, 2003. First published May 20, 2003; 10.1152/ajprenal.00082.2003.— Transforming growth factor (TGF)has been associated with fibrogenesis in clinical studies and animal models. We previously showed tha...

Dupuytren’s disease is a benign fibroproliferative disease of unknown aetiology. It is often familial and commonly affects Northern European Caucasian men, but genetic studies have yet to identify the relevant genes. Transforming growth factor beta one (TGF1) is a multifunctional cytokine which plays a central role in wound healing and fibrosis. It stimulates the proliferation of fibroblasts an...

Several studies suggest an implication of transforming growth factor1 (TGF1) in the promotion of myelofibrosis associated with hematopoietic malignancies, but the involvement of this cytokine is not fully investigated. To test directly the impact of TGF1 in the pathogenesis of myelofibrosis, bone marrow stem cells from homozygous TGF1 null (TGF1 / ) and wild-type (WT) littermates were infected ...

Brief treatment with transforming growth factor (TGF)– 1 stimulated the migration of macrophages, whereas long-term exposure decreased their migration. Cell migration stimulated by TGF1 was markedly inhibited by 10 g/mL Tat-C3 exoenzyme. TGF1 increased mRNA and protein levels of macrophage inflammatory protein (MIP)–1 in the initial period, and these effects also were inhibited by 10 g/mL Tat-C...

Chin, Jeannie, Rong-Yu Liu, Leonard J. Cleary, Arnold Eskin, and John H. Byrne. TGF1-induced long-term changes in neuronal excitability in Aplysia sensory neurons depend on MAPK. J Neurophysiol 95: 3286–3290, 2006; doi:10.1152/jn.00770.2005. Transforming growth factor beta-1 (TGF1) plays important roles in the early development of the nervous system and has been implicated in neuronal plasticit...

Cao, Qi, Ki M. Mak, and Charles S. Lieber. DLPC decreases TGF1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 283: G1051–G1061, 2002; 10.1152/ajpgi.00128.2002.— Dilinoleoylphosphatidylcholine (DLPC), the active component of polyenylphosphatidylcholine extracted from soybeans, decreases collagen accumulation induced by TGF1 in cult...

Transgenic mice that overexpress cyclin D1 protein in the liver develop liver carcinomas with high penetrance. Transforming growth factor (TGF) serves as either an epithelial cell growth inhibitor or a tumor promoter, depending on the cellular context. We interbred LFABP-cyclin D1 and Alb-TGF1 transgenic mice to produce cyclin D1/TGF1 double transgenic mice and followed the development of liver...

Retinoic acid and transforming growth factor(TGF) affect differentiation, proliferation and carcinogenesis of epithelial cells. The effect of both compounds on the proliferation of cells of the hormone sensitive human breast cancer cell line (ER+) MCF-7 was assessed in the presence of estradiol and tamoxifen. The assay was based on [H]thymidine incorporation and the proliferative activity of PC...

Disruption of stromal cell-derived factor-1 (SDF-1/CXCL12 [CXC chemokine ligand 12]) interaction leads to mobilization of stem/ progenitor cells from bone marrow to circulation. However, prolonged exposure of CD34 cells to SDF-1 desensitizes them to SDF-1. So how do cells remain responsive to SDF-1 in vivo when they are continuously exposed to SDF-1? We hypothesized that one or more mechanisms ...