PURPOSE The elucidation of thalamocortical connections between the mediodorsal nucleus (MD) of thalamus and the prefrontal cortex (PFC) is important in the clinical fields of neurorehabilitation and psychiatry. However, little is known about these connections in human brain. We attempted to identify and investigate the anatomical characteristics of the thalamocortical connection between MD and ...

embryogenesis, the ventral telencephalon (VT) plays a major role in the early development of these tracts. First, two populations of pioneer neurons allow corticothalamic (CTA) and thalamocortical axons (TCA) to enter the VT. Secondly, the VT forms a permissive corridor which guides TCAs through the MGE. Finally, thalamortical and corticothalamic axons guide each other once they have met in the...

embryogenesis, the ventral telencephalon (VT) plays a major role in the early development of these tracts. First, two populations of pioneer neurons allow corticothalamic (CTA) and thalamocortical axons (TCA) to enter the VT. Secondly, the VT forms a permissive corridor which guides TCAs through the MGE. Finally, thalamortical and corticothalamic axons guide each other once they have met in the...

embryogenesis, the ventral telencephalon (VT) plays a major role in the early development of these tracts. First, two populations of pioneer neurons allow corticothalamic (CTA) and thalamocortical axons (TCA) to enter the VT. Secondly, the VT forms a permissive corridor which guides TCAs through the MGE. Finally, thalamortical and corticothalamic axons guide each other once they have met in the...

Change in transmitting time of impulses along axons is traditionally attributed to two parameters: the myelin formation and the diameter of neurite, both rising during the postnatal development. In the previous study, we showed that conduction velocity of the fibers projecting from the thalamus to the layer IV of the somatosensory (barrel) cortex increases as a function of age. However, the con...

The goal was to investigate possible monosynaptic GABAergic projections from the inferior colliculus (IC) to thalamocortical neurons of the medial geniculate body (MGB) in the rat. Although there is little evidence for such a projection in other sensory thalamic nuclei, a GABAergic, ascending auditory projection was reported recently in the cat. In the present study, immunohistochemical and tra...

Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal diffusion properties of the brains of migraineurs with aura, migraineurs without aura and matched healthy controls. Areas of lower fractional anisotropy were present in migraineurs along the thalamocortical tract. In...

change in transmitting time of impulses along axons is traditionally attributed to two parameters: the myelin formation and the diameter of neurite, both rising during the postnatal development. in the previous study, we showed that conduction velocity of the fibers projecting from the thalamus to the layer iv of the somatosensory (barrel) cortex increases as a function of age. however, the con...

To facilitate an understanding of auditory thalamocortical mechanisms, we have developed a mouse brain-slice preparation with a functional connection between the ventral division of the medial geniculate (MGv) and the primary auditory cortex (ACx). Here we present the basic characteristics of the slice in terms of physiology (intracellular and extracellular recordings, including current source ...

The Slit genes encode secreted ligands that regulate axon branching, commissural axon pathfinding and neuronal migration. The principal identified receptor for Slit is Robo (Roundabout in Drosophila). To investigate Slit signalling in forebrain development, we generated Robo1 knockout mice by targeted deletion of exon 5 of the Robo1 gene. Homozygote knockout mice died at birth, but prenatally d...