We applied an axisymmetric model of the tibia to a finite element method and analyzed the heat conduction from bone cement in total knee arthroplasty using numerical simulation with the finite element analysis software, ABACUS. We hypothesized the thermal necrotic map of bone. Moreover, we suggested a method for preventing thermal necrosis of bone using this simulation. We adopted an initial te...

Bone cutting is widely used in orthopaedic, dental and neuro surgeries and is a technically demanding surgical procedure. The major concern in current research is thermal damage of the bone tissue caused by high-speed power tools, which occurs when temperature rises above a certain tissue threshold value that is called bone necrosis. Hence optimization of cutting parameters is necessary to avoi...

OBJECTIVE Artifacts from gas bubble formation during radio frequency ablation along with the poor intrinsic contrast between normal and treated regions (zone of necrosis) are considerable problems for the visualization of the necrotic region on conventional sonography. Sonographic elastography is very effective for visualizing the zone of necrosis, but it uses the same echo signals to estimate ...

Whole-brain radiotherapy and stereotactic radiosurgery (SRS) play a central role in the treatment of metastatic brain tumors. Radiation necrosis occurs in 5% of patients and can be very difficult to treat. The available treatment options for radiation necrosis include prolonged high-dose corticosteroids, hyperbaric oxygen, anticoagulation, bevacizumab, and surgical resection. We present the fir...

Protein thermal stability is important for therapeutic proteins, both influencing the pharmacokinetic and pharmacodynamic properties and for stability during production and shelf-life of the final product. In this paper we show the redesign of a therapeutically interesting trimeric all-beta-sheet protein, the cytokine TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), yielding var...

A plaque assay was used to follow the inactivation kinetics of infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus in cell culture media at various temperatures. Inactivation of infectious hematopoietic necrosis virus in a visceral organ slurry was compared with that in culture media.

OBJECTIVES Do various traction techniques significantly change the anatomic position during laparoscopic cholecystectomy? METHODS 16 cadaveric liver specimens were dissected and measurements were taken between structures in the triangle of Calot. Measurements were taken while traction was placed on the infidubilum in the inferolateral, cephalad and anatomic positions. Thermal necrosis data wa...

The incidence of radiation necrosis has increased secondary to greater use of combined modality therapy for brain tumors and stereotactic radiosurgery. Given that its characteristics on standard imaging are no different that tumor recurrence, it is difficult to diagnose without use of more sophisticated imaging and nuclear medicine scans, although the accuracy of such scans is controversial. Hi...

This report describes our initial in vitro results with roboticallyassisted strain imaging for intraoperative monitoring of hepatic tumor thermal ablation. First, we demonstrate a strong correlation between thermal ablation of liver tissue and changes in elastic properties. Second, we present an experimental environment to provide controlled robotically-assisted compression of liver tissue with...