Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO(2)) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.

imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate.  these imidazo[2,1-b]thiazoles in the presence of p-tsa in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

Citation: Ibrar A, Khan A, Ali M, Sarwar R, Mehsud S, Farooq U, Halimi SMA, Khan I and Al-Harrasi A (2018) Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles. Front. Chem. 6:61. doi: 10.3389/fchem.2018.00061 Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Cou...

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects approximately 6-7 million people worldwide. Benznidazole is the only drug approved for treatment during the acute and asymptomatic chronic phases; however, its efficacy during the symptomatic chronic phase is controversial. The present work reports the synthesis and anti-T. cruzi activities of a novel ser...

Thiazolines and thiazoles are an integral part of numerous natural products, a number of drugs, and many useful molecules such as ligands for metal catalysis. We report the first common synthetic protocol for the synthesis of thiazoles and thiazolines. Novel molecules are efficiently synthesized by using readily available and inexpensive substrates. The reaction conditions are mild and pure pro...

Remarkably high-speed synthesis of 2-substituted amino-4-aryl thiazoles in polar solvents with a minimum threshold polarity index of 4.8 was found to proceed to completion in just 30-40 sec. affording excellent yields of thiazoles under ambient temperature conditions without the use of any additional catalyst. The purification-free procedure afforded libraries based around a known pharmacophore...

Ketones smoothly reacted with NBS in the presence of a catalytic amount of p-toluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and su...

Appearance and expansion of microbial resistance is one of the serious concerns in public health throughout the world. Thiazoles exhibits broad range of biological activities and was found in many active biological molecules. So far, it has proven that modifications of the thiazole ring are very effective with improved potency and less toxicity so that more than 90 % of novel drugs have the het...

Thiazolo[5,4-d]thiazoles are valuable materials for a range of technical and biological applications. They used as chemosensors, electroluminescent materials, organic light-emitting diodes (OLEDs), in solar cells, live-cell imaging, etc., those applications π-extended thiazolo[5,4-d]thiazole derivatives particularly attractive. A convenient synthetic route to non-symmetrical thiazolo[5,4-d]thia...

In the search for new fluorescent triphenylamine (TP) derivatives, we studied influence of position and substitution diverse heterocyclic substituents. A library 10 triphenylamines bearing either oxazoles or thiazoles pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C−H activation reaction between pyridine-oxazoles pyridine-thiazoles di-i...