Thyroid tissue obtained from 12 patients with Graves' disease and treated with thionamide drugs for 3-7 mo before subtotal thyroidectomy, from 12 patients with Graves' disease, similarly treated, and given 50 mug of triiodothyronine (T3) for 10 days before surgery, and from 12 euthyroid patients with solitary cold nodules was investigated to compare in vitro iodination of thyroglobulin in toxic...

the response to methimazole [1-methyl-2-mercapto-imidazole (mmi)] therapy, 10 mg twice daily in 15 patients and propylthiouracil (p tu) therapy, 100mg twice daily in 10 patients with diffuse toxic goiter was evaluated in an area of iodine deficiency (tehran). the mean free t4 index (ft4i) decreased from 22.7± 6.8 (± sd) to 10.8± 2.8 in mmi-treated, and from 25.1± 6.8 to 13.2± 2.1 in ptu-treated...

The response to methimazole [1-methyl-2-mercapto-imidazole (MMI)] therapy, 10 mg twice daily in 15 patients and propylthiouracil (P TU) therapy, 100mg twice daily in 10 patients with diffuse toxic goiter was evaluated in an area of iodine deficiency (Tehran). The mean free T4 index (FT4I) decreased from 22.7± 6.8 (± SD) to 10.8± 2.8 In MMI-treated, and from 25.1± 6.8 to 13.2± 2.1 in PTU-tr...

An additional disorder in the spectrum of thyroid related muscle disease is presented. Hypothyroid and hyperthyroid disease are both associated with a variety of muscle abnormalities, from myalgias to myopathy. Polymyositis, however, has never been reported immediately after treatment for active hyperthyroidism. A patient is presented with typical hyperthyroidism, who developed a severe proxima...

Between 1999 and June 2001, 55 unselected thyrotoxic patients were prescribed 200 MBq radioactive iodine (131I). None of these patients received a thionamide such as carbimazole or propylthiouracil within two weeks of treatment or subsequently. Symptom relief was achieved using beta blockers alone. Remission at one year was achieved in 84% of these patients and of these 62% were hypothyroid and...