Testosterone acetate thiosemicarbazone (TATSC, 17-beta-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell lin...

The tumor-inhibitory jxitency of combinations of the cupric chelate of kethoxal bis(thiosemicarbazone) [Cu(II)KTS] with several compounds that cause inhibition of the synthesis of DNA by different biochemical mechanisms was assessed in Sarcoma 180 ascites cells. Cu(II)KTS prolonged the survival time of tumor-bearing mice, whereas neither cupric chloride, copper stéarate,nor kethoxal bis(thiose...

Article history: Received on: 11/06/2013 Revised on: 29/06/2013 Accepted on: 11/07/2013 Available online: 30/07/2013 Three new chalcogenic thiosemicarbazones (3,4-difluoroacetophenone thiosemicarbazone(1), 2-bromo-4’chloroacetophenone thiosemicarbazone(2) and 2, 4’-dibromoacetophenone thiosemicarbazone(3) are synthesized by using a conventional one step processes in which the respective halo-su...

The reactions of cyclohexane-1,2-bis(4-methyl-3-thiosemicarbazone) (CHMTSC) with MCl2 (M = Co, Ni, Cu or Zn) and Cd(NO3)2 have been shown to produce complexes in which the thiosemicarbazone has been doubly deprotonated [[M(CHMTSC - 2H+)] (M = Co, Ni or Ni)], analogous to those reported earlier with other Schiff base thiosemicarbazones. However, with ZnCl2 and Cd(NO3)2, the complexes isolated ar...

This investigation involved the synthesis of metal complexes to test the hypothesis that structural changesand metal coordination in pyridine thiosemicarbazones affect cell growth and cell proliferation in vitro. Thiosemicarbazones are well known to possess antitumor, antiviral, antibacterial, antimalarial, and other activities. Extensive research has been carried out on aliphatic, aromatic, he...

The aim of the present study was to synthesize and characterize divalent metal ions Nickel, Copper Zinc complexes 5-chloro 2-furaldehyde thiosemicarbazone. Firstly ligand prepared from reaction between 5-Chloro-2-furaldehyde thiosemicarbazide, second step involved synthesis Ni(II), Cu(II) Zn(II) compounds (ligand or complex) characterized using different analytical techniques such as elemental ...

The nickel(II), copper(II), and zinc(II) complexes of the proline-thiosemicarbazone hybrids 3-methyl-(S)-pyrrolidine-2-carboxylate-2-formylpyridine thiosemicarbazone (L-Pro-FTSC or (S)-H2L(1)) and 3-methyl-(R)-pyrrolidine-2-carboxylate-2-formylpyridine thiosemicarbazone (D-Pro-FTSC or (R)-H2L(1)), as well as 3-methyl-(S)-pyrrolidine-2-carboxylate-2-formylpyridine 4,4-dimethyl-thiosemicarbazone ...

4-(p-X-phenyl)thiosemicarbazone of napthaldehyde {where X = Cl (HL¹) and X = Br (HL²)}, thiosemicarbazone of quinoline-2-carbaldehyde (HL³) and 4-(p-fluorophenyl)thiosemicarbazone of salicylaldehyde (H₂L⁴) and their copper(I) {[Cu(HL¹)(PPh₃)₂Br]·CH₃CN (1) and [Cu(HL²)(PPh₃)₂Cl]·DMSO (2)} and copper(II) {[(Cu₂L³₂Cl)₂(μ-Cl)₂]·2H₂O (3) and [Cu(L⁴)(Py)] (4)} complexes are reported herein. The synth...

A rapid and sensitive spectrophotometric method is developed for the determination of Copper (II) in aqueous DMF medium. The metal ion forms a light greenish yellow coloured complex with 5-bromo salicylaldehyde thiosemicarbazone (5-BSAT) in acidic medium. The complex shows absorption maximum at 390nm. Beer's law is obeyed in the range 0.31 – 6.35 gml -1 of Copper (II). The molar absorptivity ( ...

Discovered by Waksman et al. (1944), streptomycin was first tried extensively by Feldman and Hinshaw (1945). Synthesized in the year 1889, para-amino-salicylic acid has been studied in detail both in the United States of America and Western Europe (Lehmann, 1946). Similarly, thiosemicarbazone was developed by Professor Domagk (1946) and para-acetyl-aminobenzaldehyde thiosemicarbazone was studie...