valvular heart disease is a considerable finding in the antiphospholipid antibody syndrome (aps). the involvement of the mitral and aortic valves is more common in the form of leaflet thickening or aseptic verrucous vegetations called the libman-sacks endocarditis. in addition to the detrimental effects of endocarditis on the valves, it can lead to serious thromboembolic complications. here we ...

pulmonary thromboembolism (pte) has a wide spectrum of presentations, and its c ardinal manifestations include chest pain, dyspnea, and syncope. syncope as an initial presentation of pte occurs in 10-14% of patients and is not restricted to massive ptes. it can also occur in the setting of non- massive cases probably due to a vasovagal mechanism or the occurrence of conduction disturbances in p...

Venous thromboembolism refers to thrombotic events in the venous system that are most commonly manifested as deep vein thromboses in the upper or lower extremity and/or pulmonary embolism. Venous thromboembolism is a common disorder that is associated with significant mortality, morbidity and health care-related cost. An array of hereditary and acquired risk factors are associated with venous t...

OBJECTIVE To assess the risk of venous thromboembolism in women using hormone replacement therapy by study design, characteristics of the therapy and venous thromboembolism, and clinical background. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline. STUDIES REVIEWED Eight observational studies and nine randomised controlled trials. INCLUSION CRITERIA Studies on hormone re...

OBJECTIVE To determine the effect of sex on the risk of recurrent venous thromboembolism in all patients and in patients with venous thromboembolism that was unprovoked or provoked (by non-hormonal factors). Data source Comprehensive search of electronic databases (Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials) until July 2010, supplemented by review of conference abst...

BACKGROUND As both cancer and major orthopaedic surgery are risk factors for venous thromboembolism, patients undergoing lower-extremity oncologic endoprosthetic arthroplasty for neoplastic processes are at substantial risk of the development of symptomatic venous thromboembolism. Therefore, the primary purpose of this study was to determine the incidence of symptomatic venous thromboembolism i...

adult solid tumors: the highest risk of thromboembolism from the disease burden itself and related treatments, survival benefit of extensive cytoreductive surgery to minimize residual tumor even in cases of peritoneal seeding, and the strongest hereditary portion in adult solid tumors. Risk factors for venous thromboembolic disease includes active cancer, advanced stage, cancer type such as gyn...

The routine use of venous thromboembolism prophylaxis in patients undergoing foot and ankle procedures is not well supported in the literature. Multiple studies draw conclusions from heterogeneous populations, and specific studies have small numbers of specific pathologic conditions. Depending on the study, recommendations for and against venous thromboembolism prophylaxis in foot and ankle sur...

superior vena cava (svc) syndrome is not an uncommon occurrence in patients with malignancy and it is often described as a medical emergency. in majority of the cases, svc syndrome occurs due to mechanical obstruction of the svc by extraluminal compression with primary intrathoracic malignancies. however, intraluminal obstruction due to thrombosis can also produce symptoms and signs of svc synd...