Dysregulation of miR-224 has been shown to be involved in cancer tumorigenesis and progression of several cancer types. However, its expression patterns in tumors are controversial. The aim of this study was to determine the expression and clinical significance of miR-224 in pediatric acute myeloid leukemia (AML). Expression levels of miR-224 in bone marrow mononuclear cells were detected by re...

"' Feingold, D. S., E. F. Neufeld, and W. Z. Hassid (in preparation). 68 Feingold, D. S., E. F. Neufeld, and W. Z. Hassid, Fed. Proc., 18, 224 (1959); Neufeld, E. F., D. S. Feingold, and W. Z. Hassid, Arch. Biochem. and Biophys. (in press). 59 Neufeld, E. F., D. S. Feingold, and W. Z. Hassid, Am. Chem. Soc. Abstracts, 60, April 1959. 60 Barker, S. A., E. J. Bourne, J. G. Fleetwood, and M. Stace...

INTRODUCTION The extensive use of prostate-specific antigen as a general prostate cancer biomarker has introduced the hazards of overdiagnosis and overtreatment. Recent studies have revealed the immense biomarker capacity of microRNAs (miRNAs) in prostate cancer. The aim of this study was to analyze the expression pattern of miR-224, a cancer-related miRNA, in prostate tumors and investigate it...

Let f be a meromorphic, transcendental function in the finite plane having a finite number of a-points. The well-known theorem of Iversen [i, p. 224] asserts that in this case there exists a curve F going out to such that f(z) -~ a as z ~ ~, z ~ F. Such a curve is called an asymptotic curve. We henceforth make use of the standard notation from the theory of meromorphic functions [1] without spe...

BACKGROUND MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development. METHODS Using real-time quantitative RT-PCR, we detected miR-224...

Little is known about the function of microRNA-224 (miR-224) in medullary thyroid cancer (MTC). This study investigated the role of miR-224 expression in MTC and correlated it with mutation status in sporadic MTCs. A consecutive series of 134 MTCs were considered. Patients had a sporadic form in 80% of cases (107/134). In this group, REarranged during transfection (RET) and rat sarcoma (RAS) mu...

UNLABELLED In hepatocellular carcinoma (HCC), dysregulated expression of microRNA-224 (miR-224) and impaired autophagy have been reported separately. However, the relationship between them has not been explored. In this study we determined that autophagy is down-regulated and inversely correlated with miR-224 expression in hepatitis B virus (HBV)-associated HCC patient specimens. These results ...

Background: Exogenous gamma-hydroxybutyrate (GHB) increases slow-wave sleep and reduces daytime sleepiness and cataplexy in patients with primary narcolepsy. Objective: To examine nighttime sleep and daytime sleepiness in a 13year-old girl homozygous for succinic semialdehyde dehydrogenase (SSADH) deficiency, a rare recessive metabolic disorder that disrupts the normal degradation of 4-aminobut...