Although current influenza vaccines are effective in general, there is an urgent need for the development of new technologies to improve vaccine production timelines, capacities and immunogenicity. Herein, we describe the development of an influenza vaccine technology which enables recombinant production of highly efficient influenza vaccines in bacterial expression systems. The globular head d...

After several decades of vaccination against hepatitis B virus in newborns, infants, adolescents, and adults, the question remains whether a booster dose is ever needed. Long-term protection is most commonly measured through 4 methods: the anamnestic response after administration of a booster dose, infection rate in vaccinated populations, in vitro B and T cell activity testing, and seroepidemi...

We study the use of temporal information in the form of timelines to enhance multidocument summarization. We employ a fully automated temporal processing system to generate a timeline for each input document. We derive three features from these timelines, and show that their use in supervised summarization lead to a significant 4.1% improvement in ROUGE performance over a state-of-the-art basel...

As search applications keep gathering new and diverse information sources, presenting relevant information anchored in time becomes more important. Temporal information is available in every document either explicitly, e.g., in the form of temporal expressions, or implicitly in the form of metadata. Recognizing such temporal information and exploiting it for document retrieval and presentation ...

Across many cultures, people create spatial representations of time. The direction of mental timelines often follows the direction of writing in a person's language. A new study demonstrates that blind participants (who read with their hands) also show mental timelines that follow reading direction.

Historical data items are often semantically inter-related, such as news events that build on past events. Such inter-related data have so far been visualized primarily with simple timeline interfaces, which tend to not scale well, and which do not illustrate important semantic relationships among the data. An improved technique would be useful in news analysis, social and historical research, ...