BACKGROUND The effect of sublingual Timothy grass immunotherapy tablet 2800 BAU (grass SLIT-T) has been evaluated in three North American trials in adults and children who have allergic rhinitis with or without conjunctivitis (AR/C). This paper examines the effects of grass SLIT-T in Canadians. METHODS Data for grass-allergic Canadians in three randomized, placebo-controlled, double-blind tri...

BACKGROUND The ImmunoCAP ISAC 112 platform is the only commercially available molecular allergy IgE multiplex test. Data on the comparison of this rather novel test with the molecular singleplex ImmunoCAP IgE platform are lacking. OBJECTIVE To compare the multiplex ISAC 112 platform and the singleplex ImmunoCAP platform in regard to IgE to grass pollen allergens in untreated grass pollen-alle...

BACKGROUND Grass pollens are significant elicitors of IgE-mediated allergic disease in the world and timothy (Phleum pratense) is one of the most important pollens of the family. Molecular and biochemical characterization of Phleum pratense has revealed several allergen components: rPhl p 1 and rPhl p 5 have been shown to be "Species Specific Allergens", while the profilin rPhl p 12 and the cal...

BACKGROUND Grass pollen, in particular from Lolium multiflorum is a major allergen source in temperate climate zones of Southern Brazil. The IgE sensitization profile of Brazilian grass pollen allergic patients to individual allergen molecules has not been analyzed yet. OBJECTIVE To analyze the IgE sensitization profile of a Brazilian grass pollen allergic population using individual allergen...

Methods A preliminary evaluation of the capabilities of the newly constructed Red Maple Trials Allergen Challenge Theatre was performed. Health Canada and a provincial Ethics Board approved the study. After signing informed consent, patients with a history of grass allergy, not on allergy medications and with a positive skin prick test to grass antigen (≥ 3 mm) were exposed for 3 hours to timot...

number of dead corms per plant by up to 93% and decreases living corm mass by up to 29% (Peters, 1958). Cultivated timothy (Phleum pratense L.) is an important grass for Harvesting frequently, up to three or four cuts per year, hay production in temperate North America. It is underutilized in and season-long competition in a timothy–alfalfa (Medmanagement-intensive rotational grazing systems be...

Methods The subjects were 12,469 school students (6,440 girls and 6,029 boys) in 5 areas (Incheon city, Busan city, Gwangju city, Kyoungki-do, Choongchungbook-do) from 2011 to 2014. Allergic rhinitis have diagnosed with positive ‘current symptoms and sign for allergic rhinitis’ on Korean ISAAC questionnaire and 1 more than proven allergen by skin prick test. Elementary school students were test...

RATIONALE, AIMS AND OBJECTIVES The standard of preventive care for poorly controlled seasonal allergic rhinitis (AR) is subcutaneous immunotherapy (SCIT) with allergen extracts, administered in a physician's office. As an alternative to SCIT, sublingual immunotherapy (SLIT) is now an option for patients with seasonal AR. Oralair, a SLIT tablet containing freeze-dried allergen extracts of five g...