the biological mechanisms of tooth movement are based on the response of periodontal tissues to mechanical forces. the final result of these responses is remodeling of the extracellular matrix. tissue reactions may vary depending upon the type, magnitude and duration of the applied forces. the purpose of the present study was to analyze the effects of centrifugal force on the transcription of c...

background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...

Bovine trabecular cells in growth phase were exposed to cyclic mechanical stretching of the bottom of a culture dish at a cycle of 30 seconds for 72 hours. The stretched cells produced significantly larger amounts of metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after 72 hours, compared with cells in nonstretched control. In contrast, TIMP-2 and MMP-9 levels w...

Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue caused an imbalance between matrix metalloproteinases and their inhibitors. Decreased inhibitor elevated metalloproteinase levels result in collagen connective bone degradation. Several studies have shown that high of metalloproteinase-13 (MMP-13) low metallopr...

Objective(s): Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. In this study, we aimed to elucidate unclear pathogenesis of OA. Materials and Methods: Rabbit models of OA were established by the transection of the anterior cruciate ligament. Rabbits were randomly divided into three equal groups: the experimental group (OA modeling, treated with e...

Introduction: Chronic periodontitis is a multifactorial disease that causes rapid destruction of the tissues supporting teeth and may lead to tooth loss. Matrix metalloproteinase-13 (MMP‐13) levels have been higher in gingival crevicular fluid chronic patients tissue inhibitor metalloproteinase-1 (TIMP‐1) an endogenous MMPs implicated inflammation. This review purpose discuss relationship betwe...