Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7-deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma (HNSCC) cell lines ...

Technology now at hand can integrate all kinds of digital information for individuals, groups, and organizations so their information usefully links together. iInfoTM information integration works by making connections including examples like the following:  A statistical connection between “being in a traffic jam” and “driving in downtown Trenton between 5PM and 6PM on a weekday.”  A termino...

Herein, utilizing density functional theory (DFT) calculations, we have assessed the feasibility of single-atom-embedded C3N with various coordination environments TM-C3, TM-C2N1, TM-C4, and TM-C2N2 for oxygen electrocatalysis. It has been proved that most TM-CxNy candidates are stable all them possess metallic features to ensure fast electron transfer. Importantly, Co-C2N2 is a bifunctional no...

We calculate analytically the probability density P (tm) of the time tm at which a continuous-time Brownian motion (with and without drift) attains its maximum before passing through the origin for the first time. We also compute the joint probability density P (M, tm) of the maximum M and tm. In the driftless case, we find that P (tm) has power-law tails: P (tm) ∼ t −3/2 m for large tm and P (...