UNLABELLED Time-of-flight (TOF) PET uses very fast detectors to improve localization of events along coincidence lines-of-response. This information is then utilized to improve the tomographic reconstruction. This work evaluates the effect of TOF upon an observer's performance for detecting and localizing focal warm lesions in noisy PET images. METHODS An advanced anthropomorphic lesion-detec...

Objective(s): Yttrium-90 (90Y) is a beta particle nuclide used in targeted radionuclide therapy which is available to both single-photon emission computed tomography (SPECT) and time-of-flight (TOF) positron emission tomography (PET) imaging. The purpose of this study was to assess the image quality of PET and Bremsstrahlung SPECT by simulating PET and SPECT images of 90Y using Monte Carlo simu...

While the first time-of-flight (TOF)-positron emission tomography (PET) systems were already built in the early 1980s, limited clinical studies were acquired on these scanners. PET was still a research tool, and the available TOF-PET systems were experimental. Due to a combination of low stopping power and limited spatial resolution (caused by limited light output of the scintillators), these s...

We present the most recent advances in photo-detector design employed in time of flight positron emission tomography (ToF-PET). PET is a molecular imaging modality that collects pairs of coincident (temporally correlated) annihilation photons emitted from the patient body. The annihilation photon detector typically comprises a scintillation crystal coupled to a fast photo-detector. ToF informat...

objective(s): the present study was conducted to examine whether the standardized uptake value (suv) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (pet) images, obtained via two methods based on time-of-flight (tof) reconstruction and point spread function (psf). methods: a cylinder phantom with the sphere (30mm diameter), located in...

This paper explores fast reconstruction strategies for 3D time-of-flight (TOF) PET, based on 2D data rebinning. We introduce TOF-FORE, an approximate rebinning algorithm obtained by extending the Fourier rebinning method for non-TOF data. In addition, we identify two partial differential equations that must be satisfied by consistent 3D TOF data, and use them to derive exact rebinning algorithm...

BACKGROUND Our aim was to evaluate if a recently introduced TOF PET system with digital photon counting technology (Philips Healthcare), potentially providing an improved image quality over analogue systems, can fulfil EANM research Ltd (EARL) accreditation specifications for tumour imaging with FDG-PET/CT. FINDINGS We have performed a phantom study on a digital TOF PET system using a NEMA NU...

National Taiwan University, Taipei, Taiwan A quantitative reconstruction of radiotracer activity distribution in positron emission tomography (PET) requires correction of attenuation, which was typically estimated through transmission measurements. The advancement in hardware development has prompted the use of time-of-flight (TOF) to improve PET imaging. Recently, the application of TOF-PET ha...

UNLABELLED Precise assessment of lymph node metastases is critical to the treatment outcome and overall survival of patients with head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to investigate the effect of time-of-flight (TOF) technique on the diagnostic performance of (18)F-FDG PET/CT for assessment of lymph node metastases in HNSCC patients. METHODS In 39 patie...

Simple theory predicts that the statistical noise variance in PET can be reduced by an order of magnitude by using time-of-flight (TOF) information. This reduction can be obtained by improving the coincidence timing resolution, and so would be achievable in clinical, whole body studies using with PET systems that differ little from existing cameras. The potential impact of this development is l...