The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology...

16:00: An 81 year-old woman was admitted to the emergency department with nausea, vomiting and hypotension. She had a history of hypertension, Type II Diabetes, renal insufficiency and dementia. Home medications: aspirin, furosemide, tolterodine tartrate, memantine, Valsartan, metformin, Lovastatin and niacin. On admission she presented with low grade fever 37.9, a blood pressure (BP) of 60/30 ...

OBJECTIVES To compare the efficacy of tolterodine plus simplified bladder training (BT) with tolterodine alone in patients with an overactive bladder. PATIENTS AND METHODS In a multicentre, single-blind study at 51 Scandinavian centres, 505 patients aged >or= 18 years with symptoms of urinary frequency (>or= 8 micturitions/24 h) and urgency, with or without urge incontinence, were randomized ...

A simple, selective, precise and stability-indicating high-performance liquid chromatographic (HPLC) method of analysis tolterodine tartrate in pharmaceutical dosage form was developed and validated. The chromatographic conditions comprised a reversed-phase C18 column (250 × 4.6 mm), 5 μ with a mobile phase consisting of a mixture of buffer solution (2.88 g ammonium dihydrogen orthophosphate in...

A single organic counterion analysis method was developed by using an ion chromatography separation technique and conductivity detector. This allows the rapid characterization of an API to support clinical studies and to fulfil the regulatory requirements for the quantitation of fumarate, oxalate, succinate, and tartrate counterions in active pharmaceutical ingredients (quetiapine fumarate, esc...

OBJECTIVES To explore in the daily clinical practice setting that antimuscarinic, Fesoterodine or Solifenacin, provides a greater clinical benefit after changing their prior Overactive Bladder (OAB) therapy with tolterodine extended-release (ER) to other novel antimuscarinic agents. MATERIAL AND METHODS A post-hoc analysis of data from an observational multicenter, cross-sectional, retrospect...